Skip to Content

IPlex Side Effects

Generic Name: mecasermin rinfabate

Note: This document contains side effect information about mecasermin rinfabate. Some of the dosage forms listed on this page may not apply to the brand name iPlex.

Applies to mecasermin rinfabate: subcutaneous solution


Endocrine side effects have included hypoglycemia, hyperglycemia, tonsilar hypertrophy, adenoid hypertrophy, lymphadenopathy, and thyromegaly.[Ref]


Local side effects have included erythema, lipohypertrophy and hair growth at the injection sites.[Ref]


Ocular side effects have included papilledema, possibly due to increased intracranial pressure.[Ref]

Nervous system

Nervous system side effects have included headaches.[Ref]


Hepatic side effects have included increases in liver size, and increased transaminase (AST) and LDH levels,[Ref]


Hematologic side effects have included iron deficiency anemia and increased size of the spleen.[Ref]


Musculoskeletal side effects have included arthralgia, bone pain, muscular atrophy, and pain in an extremity.[Ref]


Renal side effects have included increases in kidney size.[Ref]


Genitourinary side effects have included ovarian cysts.[Ref]


Cardiovascular side effects have included echographic evidence of valvulopathy.[Ref]


1. "Multum Information Services, Inc. Expert Review Panel"

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

More about iPlex (mecasermin rinfabate)

Consumer resources

Related treatment guides