Fyarro Side Effects

Generic name: sirolimus protein-bound

Medically reviewed by Drugs.com. Last updated on Feb 11, 2024.

Note: This document contains side effect information about sirolimus protein-bound. Some dosage forms listed on this page may not apply to the brand name Fyarro.

Applies to sirolimus protein-bound: intravenous powder for suspension.

Serious side effects of Fyarro

Along with its needed effects, sirolimus protein-bound (the active ingredient contained in Fyarro) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sirolimus protein-bound:

More common

Bleeding gums
blood in the urine or stools
blurred vision
chest pain
chills
confusion
cough
coughing up blood
cracked lips
decreased urine
diarrhea
difficulty in swallowing
dizziness
dry mouth
fever
flushed, dry skin
fruit-like breath odor
general feeling of discomfort or illness
headache
increased hunger
increased menstrual flow or vaginal bleeding
increased thirst
increased urination
irritation or soreness of the mouth
lightheadedness
loss of appetite
mood changes
muscle pain or cramps
nausea or vomiting
nervousness
nosebleeds
numbness or tingling in hands, feet, or lips
painful or difficult urination
pale skin
paralysis
pinpoint red spots on the skin
pounding in the ears
prolonged bleeding from cuts
red or dark brown urine
red or black, tarry stools
slow, fast, or irregular heartbeat
sore throat
sores, ulcers, or white spots on the lips, tongue, or inside the mouth
stomach pain
sunken eyes
sweating
swelling of the hands, ankles, feet, or lower legs
thickening of bronchial secretions
trouble breathing
unexplained weight loss
unusual bleeding or bruising
unusual tiredness or weakness
wrinkled skin

Other side effects of Fyarro

Some side effects of sirolimus protein-bound may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bleeding after defecation
burning, numbness, tingling, or painful sensations
constipation
discoloration of the fingernails or toenails
dry skin
loss or thinning of the hair
muscle or bone pain
trouble sleeping
uncomfortable swelling around the anus
unsteadiness or awkwardness
weakness in arms, hands, legs, or feet

For Healthcare Professionals

Applies to sirolimus protein-bound: intravenous powder for injection.

General

The most common adverse reactions were stomatitis (79%), fatigue and rash (68% each), infection (59%), nausea and edema (50% each), and diarrhea, musculoskeletal pain, and decreased weight (47% each).^[Ref]

Cardiovascular

Very common (10% or more): Hypertension (29%)^[Ref]

Dermatologic

Very common (10% or more): Rash (68%), alopecia (24%), pruritus (18%)

Dry skin (12%), nail disorder (12%)^[Ref]

Gastrointestinal

Very common (10% or more): Stomatitis (79%), nausea (50%), diarrhea (47%), vomiting (32%), abdominal pain (29%), constipation (24%), dry mouth (15%), hemorrhoids (12%)^[Ref]

Hematologic

Very common (10% or more): Hemorrhage (24%)^[Ref]

Metabolic

Very common (10% or more): Decreased appetite (444%), dehydration (15%)^[Ref]

Musculoskeletal

Very common (10% or more): Musculoskeletal pain - including arthralgias, back pain, myalgias (47%)^[Ref]

Ocular

Very common (10% or more): Blurred vision (12%)^[Ref]

Other

Very common (10% or more): Infections - upper respiratory tract infection, urinary tract infection, sinusitis, skin infection, folliculitis, nasopharyngitis, pharyngitis, pharyngitis streptococcal, pneumonia, vaginal infection (59%)^[Ref]