Etranacogene Dezaparvovec Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 20, 2024.

Applies to etranacogene dezaparvovec: intravenous suspension.

Serious side effects

Along with its needed effects, etranacogene dezaparvovec may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking etranacogene dezaparvovec:

More common side effects

• dizziness
• facial swelling
• fever or chills
• headache
• nausea or vomiting
• skin rash
• trouble breathing
• weakness

Less common side effects

• chest discomfort or tightness
• fast, pounding, or irregular heartbeat or pulse
• hives, itching
• irritation
• joint pain, stiffness, or swelling
• redness or the skin
• swelling of the eyelids, face, lips, hands, or feet

Other side effects

Some side effects of etranacogene dezaparvovec may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• cough
• diarrhea
• general feeling of discomfort or illness
• loss of appetite
• muscle aches and pains
• runny nose
• shivering
• sore throat
• sweating
• trouble sleeping
• unusual tiredness or weakness

Less common side effects

• stomach pain

For healthcare professionals

Applies to etranacogene dezaparvovec: intravenous suspension.

General adverse events

The most common adverse reactions reported were alanine amino transaminase (ALT) elevations, headache, blood creatine kinase elevations, flu-like symptoms, infusion-related reactions, fatigue, malaise, and aspartate transaminase (AST) elevations.^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea^[Ref]

Hepatic

• Very common (10% or more): Elevated ALT (42%), elevated AST (42%)^[Ref]

Hypersensitivity

• Very common (10% or more): Infusion-related reactions (33%)
• Common (1% to 10%): Hypersensitivity^[Ref]

Local

• Very common (10% or more): Malaise (12%)^[Ref]

Musculoskeletal

• Very common (10% or more): Increased blood creatine kinase (42%)

Other

• Very common (10% or more): Fatigue (12%), flu-like symptoms (14%)^[Ref]

Nervous system

• Very common (10% or more): Headache (18%)^[Ref]

Further information

Etranacogene dezaparvovec side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer