Etranacogene Dezaparvovec Side Effects

Medically reviewed by Drugs.com. Last updated on Jun 7, 2024.

Applies to etranacogene dezaparvovec: intravenous suspension.

Precautions

It is very important that your doctor check you closely and at regular visits to make sure this medicine is working properly. Blood tests will be needed to check for unwanted effects.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Tell your doctor or nurse right away if you have a rash, itching skin, difficulty with swallowing, dizziness, a fast heartbeat, lightheadedness or fainting, restlessness, trouble breathing, swelling in your face, hands, tongue, or throat, or chest pain after you receive the medicine.

Check with your doctor right away if you have clay-colored stool, dark urine, decreased appetite, fever, itching, loss of appetite, nausea and vomiting, skin rash, stomach pain, swelling of the feet or lower legs, unusual tiredness or weakness, or yellow eyes or skin. These may be symptoms of a serious liver problem.

Serious side effects

Along with its needed effects, etranacogene dezaparvovec may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking etranacogene dezaparvovec:

Other side effects

Some side effects of etranacogene dezaparvovec may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to etranacogene dezaparvovec: intravenous suspension.

General adverse events

The most common adverse reactions reported were alanine amino transaminase (ALT) elevations, headache, blood creatine kinase elevations, flu-like symptoms, infusion-related reactions, fatigue, malaise, and aspartate transaminase (AST) elevations.^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea^[Ref]

Hepatic

• Very common (10% or more): Elevated ALT (42%), elevated AST (42%)^[Ref]

Hypersensitivity

• Very common (10% or more): Infusion-related reactions (33%)
• Common (1% to 10%): Hypersensitivity^[Ref]

Local

• Very common (10% or more): Malaise (12%)^[Ref]

Musculoskeletal

• Very common (10% or more): Increased blood creatine kinase (42%)

Other

• Very common (10% or more): Fatigue (12%), flu-like symptoms (14%)^[Ref]

Nervous system

• Very common (10% or more): Headache (18%)^[Ref]

See also:

Further information

Etranacogene dezaparvovec side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer