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Cocaine topical Side Effects

Medically reviewed by Last updated on Feb 19, 2024.

Applies to cocaine topical: topical solution.


Topical route (Solution)

Not for injection or ophthalmic use.

Serious side effects of Cocaine topical

Along with its needed effects, cocaine topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking cocaine topical:

Less common or Rare

Other side effects of Cocaine topical

Some side effects of cocaine topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to cocaine topical: compounding powder, topical solution.

Nervous system

Nervous system side effects have included nervousness, restlessness, excitement, tremors, and seizures (tonic-clonic).[Ref]


Cardiovascular side effects have included vasoconstriction, bradycardia associated with small doses, and increased heart rate associated with moderate doses.[Ref]


Respiratory side effects have included fatal respiratory failure secondary to depression of the central nervous system.[Ref]


Ocular side effects have included mydriasis. Sloughing of the corneal epithelium, clouding, pitting, and corneal ulceration have been reported.[Ref]


Gastrointestinal side effects have included vomiting.[Ref]


In general, most side effects are probably due to the high plasma drug levels resulting from excessive and rapid absorption of cocaine topical.[Ref]


1. Product Information. Cocaine Hydrochloride (cocaine topical). Mallinckrodt Medical Inc. 2003.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.