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Cocaine topical Side Effects

For the Consumer

Applies to cocaine topical: topical paste, topical solution

Along with its needed effects, cocaine topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking cocaine topical:

Less common or Rare
  • Abdominal or stomach pain
  • chills
  • confusion
  • dizziness or lightheadedness
  • excitement, nervousness, restlessness, or any mood or mental changes
  • fast or irregular heartbeat
  • general feeling of discomfort or illness
  • hallucinations or seeing, hearing, or feeling things that are not there
  • headache (sudden)
  • increased sweating
  • nausea

Some side effects of cocaine topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Loss of sense of taste or smell (after use in the nose or mouth)

For Healthcare Professionals

Applies to cocaine topical: compounding powder, topical solution

Nervous system

Nervous system side effects have included nervousness, restlessness, excitement, tremors, and seizures (tonic-clonic).[Ref]


Cardiovascular side effects have included vasoconstriction, bradycardia associated with small doses, and increased heart rate associated with moderate doses.[Ref]


Respiratory side effects have included fatal respiratory failure secondary to depression of the central nervous system.[Ref]


Ocular side effects have included mydriasis. Sloughing of the corneal epithelium, clouding, pitting, and corneal ulceration have been reported.[Ref]


Gastrointestinal side effects have included vomiting.[Ref]


In general, most side effects are probably due to the high plasma drug levels resulting from excessive and rapid absorption of cocaine topical.[Ref]


1. "Product Information. Cocaine Hydrochloride (cocaine topical)." Mallinckrodt Medical Inc, St. Louis, MO.

Some side effects of cocaine topical may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.