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Cerdelga Side Effects

Generic Name: eliglustat

Note: This document contains side effect information about eliglustat. Some of the dosage forms listed on this page may not apply to the brand name Cerdelga.

In Summary

Common side effects of Cerdelga include: arthralgia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to eliglustat: oral capsule

Along with its needed effects, eliglustat (the active ingredient contained in Cerdelga) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking eliglustat:

Less common
  • Fast, irregular, pounding, or racing heartbeat or pulse
Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking eliglustat:

Symptoms of overdose
  • Blurred vision
  • chest pain or discomfort
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • nausea
  • shortness of breath
  • sweating
  • unusual tiredness or weakness
  • vomiting

Some side effects of eliglustat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Acid or sour stomach
  • back pain
  • belching
  • bloated
  • cough
  • diarrhea
  • difficulty with moving
  • excess air or gas in the stomach or intestines
  • full feeling
  • headache
  • heartburn
  • indigestion
  • lack or loss of strength
  • muscle pain or stiffness
  • pain in the arms or legs
  • pain in the joints
  • passing gas
  • sore throat
  • stomach discomfort, upset, or pain
  • upper abdominal or stomach pain
Less common
  • Difficulty having a bowel movement (stool)
  • rash

For Healthcare Professionals

Applies to eliglustat: oral capsule


Common (1% to 10%): Palpitations[Ref]


Common (1% to 10%): Rash[Ref]


Very common (10% or more): Nausea (up to 12%), diarrhea (up to 12%), oropharyngeal pain (up to 10%)
Common (1% to 10%): Flatulence, dyspepsia, gastroesophageal reflux disease, constipation[Ref]


The most frequently reported side effects (occurring in 10% or more of patients) included fatigue, headache, nausea, diarrhea, back pain, pain in extremities, and upper abdominal pain.[Ref]


Very common (10% or more): Arthralgia (up to 45%), back pain (up to 12%), pain in extremity (up to 11%), upper abdominal pain (up to 10%)
Common (1% to 10%): Asthenia[Ref]

Nervous system

Very common (10% or more): Headache (up to 40%), migraine (up to 10%)
Common (1% to 10%): Dizziness[Ref]


Very common (10% or more): Fatigue (up to 14%)[Ref]


Common (1% to 10%): Cough[Ref]


1. "Product Information. Cerdelga (eliglustat)." Genzyme Corporation, Cambridge, MA.

Some side effects of Cerdelga may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.