Aquamephyton Side Effects
Generic name: phytonadione
Medically reviewed by Drugs.com. Last updated on Feb 28, 2024.
Note: This document contains side effect information about phytonadione. Some dosage forms listed on this page may not apply to the brand name Aquamephyton.
For Healthcare Professionals
Applies to phytonadione: compounding powder, injectable solution, oral tablet.
Local
Rare (less than 0.1%): Injection site reactions (inflammation, atrophy, necrosis)
Very rare (less than 0.01%): Venous irritation or phlebitis (IV route)
Frequency not reported: Pain, swelling, and tenderness at the injection site[Ref]
Cardiovascular
Rare (less than 0.1%): Rapid and weak pulse, hypotension, cyanosis
Very rare (less than 0.01%): Facial flushing
Postmarketing reports: Tachycardia, flushing[Ref]
Hypersensitivity
Very rare (less than 0.01%): Anaphylactoid reactions (IV route)
Frequency not reported: Allergic sensitivity, anaphylaxis
Postmarketing reports: Fatal hypersensitivity reaction[Ref]
Fatalities and other severe reactions have occurred during or immediately after the parenteral administration of phytonadione. The majority of these reactions have occurred with intravenous administration. These reactions resemble hypersensitivity or anaphylaxis and include shock and cardiac or respiratory arrest. Feelings of uneasiness, flushing, diaphoresis, chest pain, tachycardia, cyanosis, weakness, and dyspnea may precede the cardiopulmonary event. These severe reactions are more likely with, but are not limited to, rapid infusions of undiluted drug.[Ref]
Gastrointestinal
Gastrointestinal side effects have rarely included 'peculiar' sensations of taste.
Respiratory
Rare (less than 0.1%): Dyspnea[Ref]
Other
Frequency not reported: Death (IV and IM routes)[Ref]
Dermatologic
Uncommon (0.1% to 1%): Erythematous, indurated, pruritic plaques
Rare (less than 0.1%): Profuse sweating, scleroderma-like lesions,
Very rare (less than 0.01%): Sweating
Frequency not reported: Erythema perstans-like lesions[Ref]
Nervous system
Rare (less than 0.1%): Dizziness
Very rare (less than 0.01%): Unusual taste
Postmarketing reports: Dysgeusia[Ref]
Hepatic
Rare (less than 0.1%): Hyperbilirubinemia
Frequency not reported: Jaundice in newborns[Ref]
Hyperbilirubinemia occurred primarily with doses above those recommended.[Ref]
Hematologic
Frequency not reported: Hemolysis in newborns[Ref]
General
The most common adverse events were dermatologic and injection site reactions.[Ref]
More about Aquamephyton (phytonadione)
- Check interactions
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- Latest FDA alerts (1)
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- During pregnancy
- Drug class: anticoagulant reversal agents
- Breastfeeding
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References
1. Product Information. Vitamin K (phytonadione). Apothecon Inc. 2022.
2. Cerner Multum, Inc. UK Summary of Product Characteristics.
3. Cerner Multum, Inc. Australian Product Information.
4. Product Information. Mephyton (phytonadione). Merck & Co., Inc. 2001;PROD.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.