Amondys 45 Side Effects

Generic name: casimersen

Medically reviewed by Drugs.com. Last updated on Dec 3, 2024.

Note: This document provides detailed information about Amondys 45 Side Effects associated with casimersen. Some dosage forms listed on this page may not apply specifically to the brand name Amondys 45.

Applies to casimersen: intravenous solution.

Serious side effects of Amondys 45

Along with its needed effects, casimersen (the active ingredient contained in Amondys 45) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking casimersen:

More common side effects

• body aches or pain
• chills
• cough
• difficulty in moving
• dizziness
• ear congestion
• fast, pounding, or irregular heartbeat
• fever
• headache
• joint pain
• lightheadedness
• loss of voice
• muscle pain or stiffness
• nausea
• runny or stuffy nose
• sneezing
• sore throat
• stomach pain
• swelling of the face, ankles, or hands
• tender, swollen glands in the neck
• trouble breathing
• trouble swallowing
• unusual tiredness or weakness
• vomiting

Incidence not known

• agitation
• blood in the urine
• coma
• confusion
• decreased urine output
• depression
• irritability
• lethargy
• muscle twitching
• rapid weight gain
• seizures
• stupor

Other side effects of Amondys 45

Some side effects of casimersen may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• change in hearing
• earache or pain in the ear
• ear drainage

For healthcare professionals

Applies to casimersen: intravenous solution.

General adverse events

The most commonly reported adverse reactions have included respiratory tract infection, cough, pyrexia, headache, arthralgia, and oropharyngeal pain.^[Ref]

Nervous system

• Very common (10% or more): Headache (32%)

Other

• Very common (10% or more): Pyrexia (33%)
• Frequency not reported: Ear pain, ear infection, posttraumatic pain

Musculoskeletal

• Very common (10% or more): Arthralgia (21%)

Gastrointestinal

• Very common (10% or more): Oropharyngeal pain (21%)
• Frequency not reported: Nausea

Respiratory

• Very common (10% or more): Respiratory tract infections (65%), cough (33%)

Respiratory tract infections include pharyngitis, nasopharyngitis, and rhinitis. In clinical trials, respiratory tract infections were reported in 65% of patients receiving the drug compared to 55% in the placebo group. Cough was reported in 33% of patients receiving this drug compared to 26% in placebo.

Frequently asked questions

• What are the new drugs for DMD (Duchenne muscular dystrophy)?

Further information

Amondys 45 side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer