Amondys 45 Side Effects

Generic name: casimersen

Medically reviewed by Drugs.com. Last updated on Dec 3, 2024.

Note: This document provides detailed information about Amondys 45.

Applies to casimersen: intravenous solution Side Effects associated with casimersen. Some dosage forms listed on this page may not apply specifically to the brand name Amondys 45.

Applies to casimersen: intravenous solution.

Precautions

Your doctor will check your or your child's progress closely while you are receiving this medicine to see if it is working properly and to decide if you or your child should continue to receive it. Blood and urine tests may be needed to check for unwanted effects.

Check with your doctor right away if you or your child has blood in the urine, change in frequency of urination or amount of urine, drowsiness, increased thirst, loss of appetite, nausea or vomiting, swelling of the feet or lower legs, trouble breathing, or weakness. These could be symptoms of a serious kidney problem.

Serious side effects of Amondys 45

Along with its needed effects, casimersen (the active ingredient contained in Amondys 45) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking casimersen:

Other side effects of Amondys 45

Some side effects of casimersen may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to casimersen: intravenous solution.

General adverse events

The most commonly reported adverse reactions have included respiratory tract infection, cough, pyrexia, headache, arthralgia, and oropharyngeal pain.^[Ref]

Nervous system

• Very common (10% or more): Headache (32%)

Other

• Very common (10% or more): Pyrexia (33%)
• Frequency not reported: Ear pain, ear infection, posttraumatic pain

Musculoskeletal

• Very common (10% or more): Arthralgia (21%)

Gastrointestinal

• Very common (10% or more): Oropharyngeal pain (21%)
• Frequency not reported: Nausea

Respiratory

• Very common (10% or more): Respiratory tract infections (65%), cough (33%)

Respiratory tract infections include pharyngitis, nasopharyngitis, and rhinitis. In clinical trials, respiratory tract infections were reported in 65% of patients receiving the drug compared to 55% in the placebo group. Cough was reported in 33% of patients receiving this drug compared to 26% in placebo.

See also:

Frequently asked questions

• What are the new drugs for DMD (Duchenne muscular dystrophy)?

Further information

Amondys 45 side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer