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Tetracycline Pregnancy and Breastfeeding Warnings

Tetracycline is also known as: Achromycin V, Actisite, Ala-Tet, Brodspec, Emtet-500, Panmycin, Robitet 500, Sumycin, Sumycin 250, Tetracap, Tetracon

Medically reviewed on Jan 6, 2017

Tetracycline Pregnancy Warnings

Tetracycline has been assigned to pregnancy category D by the FDA. Animal studies have revealed evidence of embryotoxicity and teratogenicity, including toxic effects on skeletal formation. There are no controlled data in human pregnancy, however, congenital defects and maternal hepatotoxicity have been reported. When used during tooth development (second half of pregnancy) tetracyclines may cause permanent yellow-gray-brown discoloration of the teeth and enamel hypoplasia. The use of tetracycline during pregnancy is generally not recommended, especially during the last half of pregnancy.

See references

Tetracycline Breastfeeding Warnings

Tetracycline is excreted into human milk in small amounts. Theoretical risks of dental staining and inhibition of bone growth exist, although are unlikely. In one study, tetracycline levels were undetectable in nursing infants. Tetracycline is considered compatible with breast-feeding by the American Academy of Pediatrics. However, the manufacturer recommends that because of the risk of serious potential adverse reactions in nursing infants, a decision should be made whether to continue breast-feeding or discontinue the drug, taking into account the importance of the drug to the mother.

See references

References for pregnancy information

  1. Koren G, Pastuszak A, Ito S "Drugs in pregnancy." N Engl J Med 338 (1998): 1128-37
  2. Whalley PJ, Martin FG, Adams RH, Combes B "Disposition of tetracycline by pregnant women with acute pyelonephritis." Obstet Gynecol 36 (1970): 821-6
  3. "Product Information. Tetracycline Hydrochloride (tetracycline)." IVAX Corporation, Miami, FL.
  4. Whalley PJ, Martin FG, Adams RH, Combes B "Tetracycline disposition in normal pregnancy." Obstet Gynecol 28 (1966): 103-11
  5. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):
  6. "Product Information. Achromycin (tetracycline)." Lederle Laboratories, Wayne, NJ.

References for breastfeeding information

  1. Committee on Drugs, 1992 to 1993 "The transfer of drugs and other chemicals into human milk." Pediatrics 93 (1994): 137-50
  2. Roberts RJ, Blumer JL, Gorman RL, et al "American Academy of Pediatrics Committee on Drugs: Transfer of drugs and other chemicals into human milk." Pediatrics 84 (1989): 924-36
  3. "Product Information. Achromycin (tetracycline)." Lederle Laboratories, Wayne, NJ.
  4. "Tetracycline in breast milk." Br Med J 4 (1969): 791
  5. "Product Information. Tetracycline Hydrochloride (tetracycline)." IVAX Corporation, Miami, FL.
  6. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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