Skip to main content

Sodium bicarbonate Pregnancy and Breastfeeding Warnings

Medically reviewed by Last updated on Nov 28, 2022.

Sodium bicarbonate is also known as: Bell/ans, Neut

Sodium bicarbonate Pregnancy Warnings

Due to the undesirable side effects of sodium loading--edema and weight gain--the use of alternative antacids has been advocated by some experts.

In one unblinded, controlled study of the maternal and fetal effects of 150 mEq of sodium bicarbonate, use of the drug was associated with significantly elevated maternal arterial pH, pC02, and base excess and significantly elevated umbilical arterial pH, p02, and base excess at delivery. There were apparent adverse effects of the infusion on the mothers, and no mention of adverse effects on the fetuses or newborns.

Sodium bicarbonate has been assigned to pregnancy category C by the FDA. There are no animal or human reproductive data. Some experts consider the use of sodium bicarbonate as an antacid during human pregnancy to be relatively contraindicated because of the availability of preferable therapeutic agents. Sodium bicarbonate should only be given during pregnancy when benefit outweighs risk.

See references

Sodium bicarbonate Breastfeeding Warnings

There are no data on the excretion of sodium bicarbonate into human milk.

See references

References for pregnancy information

  1. Coustan D, Berkowitz R, Mochizuki T. "Handbook for Prescribing Medications During Pregnancy." Boston, MA: Little, Brown, and Company (1986): 242
  2. Clark RB, Stephens SR, Greifenstein FE "Fetal and maternal effects of bicarbonate administration during labor." Anesth Analg 50 (1971): 713-8
  3. "Product Information. Sodium Bicarbonate (sodium bicarbonate)." Astra-Zeneca Pharmaceuticals (2001):

References for breastfeeding information

  1. "Product Information. Sodium Bicarbonate (sodium bicarbonate)." Astra-Zeneca Pharmaceuticals (2001):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.