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Haloperidol Pregnancy and Breastfeeding Warnings

Haloperidol is also known as: Haldol, Haldol Decanoate

Haloperidol Pregnancy Warnings

Haloperidol has been assigned to pregnancy category C by the FDA. Several cases of limb reduction malformations occurring in infants whose mothers took haloperidol during the first trimester have been reported. Other workers have not found an association with limb reductions. Haloperidol has been used in the second and third trimesters for control of chorea gravidarum and psychiatric disorders. There are no controlled data in human pregnancy. Neonates exposed to antipsychotic drugs during the third trimester of pregnancy are at risk for extrapyramidal and/or withdrawal symptoms following delivery. There have been reports of agitation, hypertonia, hypotonia, tremor, somnolence, respiratory distress and feeding disorder in these neonates. These complications have varied in severity; while in some cases symptoms have been self-limited, in other cases neonates have required intensive care unit support and prolonged hospitalization. Haloperidol is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk.

See references

Haloperidol Breastfeeding Warnings

One study has reported that levels of haloperidol excreted into human breast milk were 5 ng/mL after an average maternal dose of 30 mg/day.

Haloperidol is excreted into human milk. The American Academy of Pediatrics describes haloperidol as a drug "whose effect on nursing infants in unknown but may be of concern".

See references

References for pregnancy information

  1. Kopelman AE, McCullar FW, Heggeness L "Limb malformations following maternal use of haloperidol." JAMA 231 (1975): 62-4
  2. Donaldson JO "Control of chorea gravidarum with haloperidol." Obstet Gynecol 59 (1982): 381-2
  3. "Product Information. Haldol (haloperidol)." McNeil Pharmaceutical, Raritan, NJ.
  4. Hanson JW, Oakley GP "Haloperidol and limb deformity." JAMA 231 (1975): 26
  5. Roberts RJ, Blumer JL, Gorman RL, et al "American Academy of Pediatrics Committee on Drugs: Transfer of drugs and other chemicals into human milk." Pediatrics 84 (1989): 924-36

References for breastfeeding information

  1. Committee on Drugs, 1992 to 1993 "The transfer of drugs and other chemicals into human milk." Pediatrics 93 (1994): 137-50
  2. Roberts RJ, Blumer JL, Gorman RL, et al "American Academy of Pediatrics Committee on Drugs: Transfer of drugs and other chemicals into human milk." Pediatrics 84 (1989): 924-36
  3. Stewart RB, Karas B, Springer PK "Haloperidol excretion in human milk." Am J Psychiatry 137 (1980): 849-50
  4. "Product Information. Haldol (haloperidol)." McNeil Pharmaceutical, Raritan, NJ.
  5. Kuller JA, Katz VL, Mcmahon MJ, Wells SR, Bashford RA "Pharmacologic treatment of psychiatric disease in pregnancy and lactation: fetal and neonatal effects." Obstet Gynecol 87 (1996): 789-94

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