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Carisoprodol Pregnancy and Breastfeeding Warnings

Carisoprodol is also known as: Soma, Vanadom

Medically reviewed on December 28, 2016

Carisoprodol Pregnancy Warnings

Animal studies have reported that this drug crosses the placenta and results in adverse effects on fetal growth and postnatal survival. Animal studies have not adequately evaluated the teratogenic effects. The primary active metabolite, meprobamate, has not been shown to have a consistent association between maternal use and increased risk for particular congenital malformations. There are no controlled data in human pregnancy. Animal studies have shown reduced testes weight and sperm motility at a dose of 1200 mg/kg/day. The significance of these findings for human fertility is unknown.

US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Benefit should outweigh risk.

US FDA pregnancy category: C

See references

Carisoprodol Breastfeeding Warnings

Caution is recommended

Excreted into human milk: Yes

Comment: Monitor infant for sedation, especially if mother is concurrently taking other drugs that may cause sedation.

From 1 case report, the average dose an exclusively breastfed infant would receive was calculated at 3 mg/kg/day or about 6% of the maternal weight-adjusted dose. In animal lactation studies in mice, female pup survival and weight at weaning were decreased. This data suggests that maternal use of this drug may lead to reduced or less effective infant feeding due to sedation and/or decreased milk production.

See references

References for pregnancy information

  1. "Product Information. Soma (carisoprodol)." Meda Pharmaceuticals, Somerset, NJ.

References for breastfeeding information

  1. United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT." ([cited 2013 -]):
  2. "Product Information. Soma (carisoprodol)." Meda Pharmaceuticals, Somerset, NJ.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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