Skip to Content

Amiloride Pregnancy and Breastfeeding Warnings

Amiloride is also known as: Midamor

Amiloride Pregnancy Warnings

Three cases of amiloride exposure during pregnancy have been reported. In one, gross fetal malformations were reported following a voluntary abortion in a woman who had received amiloride, captopril and propranolol during her first trimester. Since angiotensin converting enzyme inhibitors are known teratogens, the defects were attributed to captopril. In two other cases a normal pregnancy and mild intrauterine growth retardation were reported in women treated for Bartter's syndrome and atrial fibrillation, respectively. Both infants were healthy and normal at birth.

Amiloride has been assigned to pregnancy category B by the FDA. Animal studies have revealed no evidence of teratogenicity or impaired fertility, although a decrease in rat pup growth and survival was observed at doses 5 or more times the expected maximum daily dose for humans. There are no controlled data in human pregnancy. Amiloride should only be given during pregnancy when need has been clearly established.

See references

Amiloride Breastfeeding Warnings

Animal studies have shown that amiloride is excreted into rat milk in concentrations higher than those found in blood.

There are no data on the excretion of amiloride into human milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

See references

References for pregnancy information

  1. Almeida O, Spinnato J "Maternal Bartter's syndrome and pregnancy." Am J Obstet Gynecol 160 (1989): 1225-6
  2. "Product Information. Midamor (amiloride)." Merck & Co, Inc, West Point, PA.

References for breastfeeding information

  1. "Product Information. Midamor (amiloride)." Merck & Co, Inc, West Point, PA.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.