Medically reviewed by Drugs.com. Last updated on Mar 27, 2023.
(zink KLOR ide)
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution, Intravenous [preservative free]:
Generic: 1 mg/mL (10 mL)
- Trace Element
Stored primarily in skeletal muscle and bone (>85%) (IOM 2001).
Feces and urine (IOM 2001).
Albumin and alpha 1-macroglobulin (Foote 1984).
Use: Labeled Indications
Trace element added to parenteral nutrition (PN) to prevent deficiency
Parenteral nutrition, maintenance requirement: IV: Note: Dosage expressed in terms of elemental zinc:
Acute metabolic states: 4.5 to 6 mg/day
Metabolically stable: 2.5 to 5 mg/day (ASPEN [Vanek 2012])
Stable with fluid loss from small bowel: 12.2 mg zinc/L TPN or 17.1 mg zinc/kg (added to 1000 mL IV fluids) of stool or ileostomy output
Note: Clinical response from deficiency may not occur for up to 6 to 8 weeks.
Refer to adult dosing.
Note: Dosages may be presented in units of mcg or mg, use caution to ensure correct units. Clinical response may not occur for up to 6 to 8 weeks:
Parenteral nutrition, maintenance zinc requirement: Note: Higher doses may be needed if impaired intestinal absorption or an excessive loss of zinc (eg, excessive, prolonged diarrhea, high-output intestinal fistula, burns).
Age-directed dosing (ASPEN [Vanek 2012]):
Infants <3 months: IV: 250 mcg/kg/day elemental zinc as an additive to parenteral nutrition solution.
Infants ≥3 months: IV: 50 mcg/kg/day elemental zinc as an additive to parenteral nutrition solution.
Children: 50 mcg/kg/day elemental zinc as an additive to parenteral nutrition solution; maximum daily dose: 5,000 mcg/day.
Weight-directed dosing (ASPEN [Mirtallo 2004]):
Infants <10 kg: 50 to 250 mcg/kg/day elemental zinc as an additive to parenteral nutrition solution.
Children 10 to 40 kg: 50 to 125 mcg/kg/day elemental zinc as an additive to parenteral nutrition solution; maximum daily dose: 5,000 mcg/day.
Children and Adolescents >40 kg: 2,000 to 5,000 mcg/day elemental zinc as an additive to parenteral nutrition solution.
Solution for IV injection: Administer after dilution in volume of fluid ≥100 mL
Store intact vial at 20°C to 25°C (68°F to 77°F).
Dolutegravir: Zinc Salts may decrease the serum concentration of Dolutegravir. Management: Administer dolutegravir at least 2 hours before or 6 hours after oral zinc salts. Administer the dolutegravir/rilpivirine combination product at least 4 hours before or 6 hours after oral zinc salts. Consider therapy modification
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
<1%, postmarketing, and/or case reports: Dyspepsia, hypotension, jaundice, leukopenia, nausea, neutropenia, pulmonary edema, vomiting
• Renal impairment: Use with caution in patients with renal impairment.
Concurrent drug therapy issues:
• Copper: IV administration of zinc without copper may cause a decrease in copper serum concentrations.
Dosage form specific issues:
• Aluminum: The parenteral product may contain aluminum; toxic aluminum concentrations may be seen with high doses, prolonged use, or renal dysfunction. Premature neonates are at higher risk due to immature renal function and aluminum intake from other parenteral sources. Parenteral aluminum exposure of >4 to 5 mcg/kg/day is associated with CNS and bone toxicity; tissue loading may occur at lower doses (Federal Register, 2002). See manufacturer’s labeling.
Patients on parenteral nutrition or chronic therapy should have periodic serum copper and serum zinc levels; alkaline phosphatase, taste acuity, mental depression
Pregnancy Risk Factor C Pregnancy Considerations
Zinc crosses the placenta and can be measured in the cord blood and placenta. Fetal concentrations are regulated by the placenta (de Moraes, 2011).
What is this drug used for?
• It is used to help growth and good health.
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Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.
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