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Vitamin E (Systemic)

Medically reviewed by Last updated on Oct 8, 2020.


(VYE ta min ee)

Index Terms

  • d-Alpha Tocopherol
  • dl-Alpha Tocopherol

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Capsule, Oral:

Alph-E: 400 units

Alph-E-Mixed 1000: 1000 units

Alph-E-Mixed: 200 units

Alph-E-Mixed: 400 units [corn free, milk free, sugar free, wheat free, yeast free]

Formula E 400: 400 units

Vita-Plus E: 400 units [DSC]

Generic: 180 mg, 100 units, 400 units, 1000 units, 200 units

Capsule, Oral [preservative free]:

E-400: 400 units [DSC] [corn free, gluten free, milk derivatives/products, no artificial color(s), no artificial flavor(s), sodium free, soy free, starch free, sugar free, yeast free]

E-400-Clear: 400 units [dye free]

E-400-Mixed: 400 units [dye free]

E-Max-1000: 1000 units [dye free]

Generic: 100 units, 400 units

Liquid, Oral:

Nutr-E-Sol: 400 units/15 mL (473 mL) [color free, starch free, sugar free]

Solution, Oral:

Aqueous Vitamin E: 15 units/0.3 mL (30 mL) [anise-butterscotch flavor]

SoluVita E: 50 units/mL (30 mL) [dye free, gluten free, lactose free, sugar free; contains methylparaben, polysorbate 80, propylene glycol, saccharin sodium]

Generic: 15 units/0.3 mL (12 mL [DSC], 30 mL)

Tablet, Oral:

E-Pherol: 400 units [DSC]

Natural Vitamin E: 200 units, 400 units [animal products free, gelatin free, gluten free, kosher certified, lactose free, no artificial color(s), no artificial flavor(s), starch free, sugar free, yeast free]

Generic: 100 units, 200 units, 400 units

Brand Names: U.S.

  • Alph-E [OTC]
  • Alph-E-Mixed 1000 [OTC]
  • Alph-E-Mixed [OTC]
  • Aqueous Vitamin E [OTC]
  • E-400 [OTC] [DSC]
  • E-400-Clear [OTC]
  • E-400-Mixed [OTC]
  • E-Max-1000 [OTC]
  • E-Pherol [OTC] [DSC]
  • Formula E 400 [OTC]
  • Natural Vitamin E [OTC]
  • Nutr-E-Sol [OTC]
  • SoluVita E [OTC]
  • Vita-Plus E [OTC] [DSC]

Pharmacologic Category

  • Vitamin, Fat Soluble


Prevents oxidation of vitamin A and C; protects polyunsaturated fatty acids in membranes from attack by free radicals and protects red blood cells against hemolysis


Depends on presence of bile; reduced in conditions of malabsorption, in low birth weight premature infants, and as dosage increases; water miscible preparations are better absorbed than oil preparations


To all body tissues, especially adipose tissue, where it is stored


Hepatic to glucuronides



Use: Labeled Indications

Dietary supplement

Note: According to the 2014 USPSTF recommendations for the primary prevention of cardiovascular disease and cancer, the use of vitamin E supplements are not recommended (Moyer 2014).


Hypersensitivity to vitamin E or any component of the formulation

Dosing: Adult

Vitamin E may be expressed as alpha-tocopherol equivalents (ATE), which refer to the biologically-active (R) stereoisomer content.

Dietary supplement: Oral:

Capsule, tablet: Varies by product. Dosages range from 100 to 400 units/day

Aqueous Oral Drops: 30 units/day

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Cholestasis, chronic; supplementation: Oral:

Infants: 20 to 50 units/kg/day; in the trials, a water soluble formulation was used (Corkins 2010; Sokol 1993)

Biliary atresia, post-hepatoportoenterostomy (HPE): Initial: 100 units/day using AquaADEK (2 mL); titrate dose based upon serum concentrations in 25 units/kg/day increments up to 100 units/kg/day to target alpha-tocopherol serum concentration range: 3.8 to 20.3 mcg/mL, vitamin E: Total serum lipids ratio of 0.6 mg/g; patients with a total bilirubin <2 mg/dL may require lower doses (Schneider 2012)

Children: 1 unit/kg/day; a water soluble formulation is preferred (Kliegman 2011)

Deficiency, vitamin E: Oral: Treatment (associated with malabsorption): Children: 1 unit/kg/day; adjust dose based on serum concentrations; a water soluble formulation is preferred (Kliegman 2016)

Cystic fibrosis supplementation (Borowitz 2002): Oral:

1 to 12 months: 40 to 50 units/day

1 to 3 years: 80 to 150 units/day

4 to 8 years: 100 to 200 units/day

>8 years: 200 to 400 units/day

Dietary supplement/deficiency, prevention: Aqueous Oral Drops (50 units/mL): Oral:

Infants: 5 units daily (0.1 mL)

Children <4 years: 10 units daily (0.2 mL)

Children ≥4 years and Adolescents: 30 units daily (0.6 mL)


Swallow capsules whole; do not crush or chew.

Dietary Considerations

Adequate intake (AI) (IOM 2000):

1 to 6 months: 4 mg

7 to 12 months: 5 mg

Recommended daily allowance (RDA) (IOM 2000):

1 to 3 years: 6 mg; upper limit of intake should not exceed 200 mg/day

4 to 8 years: 7 mg; upper limit of intake should not exceed 300 mg/day

9 to 13 years: 11 mg; upper limit of intake should not exceed 600 mg/day

14 to 18 years: 15 mg; upper limit of intake should not exceed 800 mg/day

>18 years: 15 mg; upper limit of intake should not exceed 1,000 mg/day

Pregnant female:

≤18 years: 15 mg; upper level of intake should not exceed 800 mg/day

19 to 50 years: 15 mg; upper level of intake should not exceed 1,000 mg/day

Lactating female:

≤18 years: 19 mg; upper level of intake should not exceed 800 mg/day

19 to 50 years: 19 mg; upper level of intake should not exceed 1,000 mg/day


Protect from light.

Drug Interactions

Agents with Antiplatelet Properties (e.g., P2Y12 inhibitors, NSAIDs, SSRIs, etc.): Vitamin E (Systemic) may enhance the antiplatelet effect of Agents with Antiplatelet Properties. Monitor therapy

Anticoagulants: Vitamin E (Systemic) may enhance the anticoagulant effect of Anticoagulants. Monitor therapy

CycloSPORINE (Systemic): Vitamin E (Systemic) may decrease the serum concentration of CycloSPORINE (Systemic). Monitor therapy

Ibrutinib: Vitamin E (Systemic) may enhance the antiplatelet effect of Ibrutinib. Monitor therapy

Orlistat: May decrease the serum concentration of Vitamins (Fat Soluble). Management: Administer oral fat soluble vitamins at least 2 hours before or after the administration of orlistat. Similar precautions do not apply to parenterally administered fat soluble vitamins. Consider therapy modification

Selumetinib: May enhance the adverse/toxic effect of Vitamin E (Systemic). Management: If selumetinib is combined with additional vitamin E supplements, ensure that the total daily intake of vitamin E (including the amount of vitamin E in selumetinib and the supplement) does not exceed the recommended or safe limits. Consider therapy modification

Tipranavir: May enhance the adverse/toxic effect of Vitamin E (Systemic). Management: Patients taking tipranavir oral solution are advised to avoid taking additional vitamin E, beyond the amounts contained in a multivitamin product. This interaction does not apply to tipranavir capsules. Consider therapy modification

Adverse Reactions

There are no adverse reactions listed in the manufacturer’s labeling.


Concerns related to adverse effects:

• Vitamin K deficiency: May induce vitamin K deficiency (Corkins 2010).

Special populations:

• Low birth weight infants: Necrotizing enterocolitis has been associated with oral administration of large dosages (eg, >200 units/day) of a hyperosmolar vitamin E preparation in low birth weight infants.

Dosage form specific issues:

• Polysorbate 80: Some dosage forms may contain polysorbate 80 (also known as Tweens). Hypersensitivity reactions, usually a delayed reaction, have been reported following exposure to pharmaceutical products containing polysorbate 80 in certain individuals (Isaksson 2002; Lucente 2000; Shelley 1995). Thrombocytopenia, ascites, pulmonary deterioration, and renal and hepatic failure have been reported in premature neonates after receiving parenteral products containing polysorbate 80 (Alade 1986; CDC 1984). See manufacturer’s labeling.

Monitoring Parameters

Plasma tocopherol concentrations

Pregnancy Considerations

Vitamin E crosses the placenta. Maternal serum concentrations of α tocopherol increase with lipid concentrations as pregnancy progresses; however, placental transfer remains constant. Additional supplementation is not needed in pregnant women without deficiency (IOM 2000).

Patient Education

What is this drug used for?

• Vitamins are needed for growth and good health.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Asthenia

• Dyspepsia

• Diarrhea

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Ecchymosis

• Hemorrhaging

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.

Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine’s uses from the patient education leaflet and is not intended to be comprehensive. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.