(sap roe TER in)
- Sapropterin Dihydrochloride
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Packet, Oral, as dihydrochloride:
Kuvan: 100 mg (1 ea, 30 ea); 500 mg (1 ea, 30 ea)
Tablet Soluble, Oral, as dihydrochloride:
Kuvan: 100 mg
Brand Names: U.S.
- Enzyme Cofactor
Sapropterin is a synthetic form of the cofactor BH4 (tetrahydrobiopterin) for the enzyme phenylalanine hydroxylase (PAH). PAH hydroxylates phenylalanine to form tyrosine. BH4 activates residual PAH enzyme, improving normal phenylalanine metabolism and decreasing phenylalanine levels in sapropterin responders. Approximately 25% to 50% of patients with PAH deficiency are responsive to sapropterin (Vockley, 2014).
Absorption is enhanced when administered with food (high fat/high calorie); absorption via intact tablet administration is greater than dissolved tablet administration.
The enzymes dihydrofolate reductase and dihydropteridine reductase are responsible for the metabolism and recycling of BH4.
Onset of Action
Within 24 hours; maximum effect: up to 1 month
Duration of Action
~7 hours (range: 4-17 hours)
Use: Labeled Indications
Hyperphenylalaninemia: To reduce blood phenylalanine (PHE) levels in patients with hyperphenylalaninemia caused by tetrahydrobiopterin (BH4)-responsive phenylketonuria in conjunction with a PHE-restricted diet.
There are no contraindications listed in the manufacturer’s labeling.
Canadian labeling: Hypersensitivity to sapropterin or any component of the formulation
Initial: 10 to 20 mg/kg once daily
Maintenance: Adjust dose after 1 month based on blood phenylalanine levels (if phenylalanine levels do not decrease from baseline after initiating 10 mg/kg, increase dose to 20 mg/kg once daily); discontinue if phenylalanine levels do not decrease after 1 month of treatment at 20 mg/kg/day (nonresponder). Maintenance range: 5 to 20 mg/kg once daily
Missed dose: A missed dose should be taken as soon as possible, but 2 doses should not be taken on the same day.
Refer to adult dosing.
Infants and Children ≥1 month to 6 years: Initial: 10 mg/kg once daily; adjust after 1 month based on blood phenylalanine levels (if phenylalanine levels do not decrease from baseline after initiating 10 mg/kg, increase dose to 20 mg/kg once daily); discontinue if phenylalanine levels do not decrease after 1 month of treatment at 20 mg/kg/day (nonresponder). Maintenance range: 5 to 20 mg/kg once daily.
Children ≥7 years and Adolescents: Refer to adult dosing.
Dosing: Renal Impairment
There are no dosage adjustments provided in manufacturer’s labeling (has not been studied). Use with caution.
Dosing: Hepatic Impairment
There are no dosage adjustments provided in manufacturer’s labeling (has not been studied). Use with caution.
Powder for oral solution: Administer with food, preferably at the same time each day. Dissolve powder for oral solution in 120 to 240 mL (4 to 8 oz) water or apple juice or in a small amount of soft foods such as apple sauce or pudding and mix thoroughly. Take within 30 minutes of dissolution.
Infants weighing 10 kg or less: Powder for oral solution can be dissolved in as little as 5 mL of water or apple juice; the appropriate dose may be administered orally via an oral dosing syringe (refer to prescribing information for dilution and administration volumes).
Tablets: Administer with food, preferably at the same time each day. Swallow tablets whole or dissolve tablets in 120 to 240 mL (4 to 8 oz) water or apple juice. May crush or stir to aid in dissolution. Take within 15 minutes of dissolution. Tablets may not dissolve completely; rinse remaining tablet residue (with more water or apple juice) and drink. Tablets may also be crushed and then mixed in a small amount of soft food such as apple sauce or pudding.
Maintain adherence to a phenylalanine-restricted diet.
Store at 20°C to 25°C (68°F to 77°F); excursions to 15°C to 30°C (59°F to 86°F) permitted. Protect from moisture.
Levodopa: Sapropterin may enhance the adverse/toxic effect of Levodopa. Monitor therapy
Methotrexate: May decrease the serum concentration of Sapropterin. Specifically, methotrexate may decrease tissue concentrations of tetrahydrobiopterin. Monitor therapy
Phosphodiesterase 5 Inhibitors: Sapropterin may enhance the hypotensive effect of Phosphodiesterase 5 Inhibitors. Monitor therapy
PRALAtrexate: May decrease the serum concentration of Sapropterin. Specifically, pralatrexate may decrease tissue concentrations of tetrahydrobiopterin. Monitor therapy
Central nervous system: Headache (15%)
Respiratory: Rhinorrhea (11%)
1% to 10%:
Gastrointestinal: Diarrhea (8%), vomiting (8%)
Respiratory: Pharyngolaryngeal pain (10%), cough (7%), rhinitis (infants and children: 7%), nasal congestion (4%)
<1%, postmarketing, case reports, and/or frequency not defined: Abdominal pain, agitation, anaphylaxis, arthralgia, dizziness, dyspepsia, esophageal pain, gastritis, gastrointestinal hemorrhage, hemorrhage (postprocedural), hyperactivity, hypersensitivity, hypophenylalaninemia, irritability, myocardial infarction, nausea, oropharyngeal pain, overstimulation, peripheral edema, pharyngitis, polyuria, respiratory failure, seizure (including seizure exacerbation), skin rash, upper abdominal pain, upper respiratory tract infection
Concerns related to adverse effects:
• Gastritis: Gastritis has been reported; monitor patients for gastritis.
• Hyperactivity: Hyperactivity has been observed; monitor patients for hyperactivity.
• Hypersensitivity: Hypersensitivity reactions, including anaphylaxis and rash, have occurred; not recommended for use in patients with a history of anaphylaxis to sapropterin. Discontinue use and initiate appropriate medical treatment in patients who experience anaphylaxis. Dietary phenylalanine (PHE) restrictions should be continued in patients who experience anaphylaxis.
• Hypophenylalaninemia: Some patients my experience low blood phenylalanine levels. Patients <7 years treated at 20 mg/kg daily are at increased risk for hypophenylalaninemia as compared to patients ≥7 years.
• Hepatic impairment: Has not been studied in patients with hepatic impairment. Monitor carefully; hepatic damage has been associated with impaired phenylalanine metabolism.
• Phenylketonuria: Phenylalanine (PHE) levels should be monitored and maintained within the target range during sapropterin treatment. Upon diagnosis, blood PHE levels should be lowered into the desired treatment range (120 to 360 micromol/L) as quickly as possible; infants with levels >600 micromol/L require treatment, although treatment may be initiated at ≥360 micromol/L; if testing is done in early infancy, it is recommended to initially lower blood PHE to 480 to 600 micromol/L (Vockley, 2014). Prolonged high levels of phenylalanine can result in severe neurologic damage, including behavioral abnormalities, delayed speech, microcephaly, seizures, and severe mental retardation. Low levels of phenylalanine are associated with catabolism and protein breakdown. Dietary management of phenylalanine intake is required to ensure nutritional balance and adequate phenylalanine control. Monitor blood PHE levels during treatment (frequently in children). PHE blood level testing at doses <20 mg/kg may underestimate response rate (Vockley, 2014).
• Renal impairment: Has not been studied in patients with renal impairment; use with caution.
Concurrent drug therapy issues:
• Drug-drug interactions: Potentially significant interactions may exist, requiring dose or frequency adjustment, additional monitoring, and/or selection of alternative therapy. Consult drug interactions database for more detailed information
• Pediatric: Children younger than 7 years treated with doses of 20 mg/kg/day are at increased risk for low levels of blood phenylalanine (hypophenylalaninemia).
• Nonresponders: Response to sapropterin treatment is established through treatment (cannot be predetermined by lab testing). Patients whose phenylalanine levels do not decrease after treatment at 20 mg/kg/day for 1 month are considered nonresponders.
Blood phenylalanine levels (baseline, after 1 week of treatment, periodically for first month, regularly thereafter); children may require more frequent monitoring; blood pressure in patients taking concomitant PDE-5 inhibitors (eg, sildenafil, vardenafil, tadalafil); patients with renal or hepatic impairment; change in neurologic status in patients taking concurrent levodopa; signs and symptoms of gastritis; hyperactivity
Guideline recommended monitoring for patients with phenylalanine hydroxylase deficiency (Vockley, 2014):
Newly diagnosed infants: Monitor phenylalanine (PHE) and tyrosine (TYR) frequently until the PHE concentrations stabilize, then monitor PHE weekly until age 1 (increase frequency during rapid growth or dietary transitions)
Children 1 to 12 years of age: Monitor PHE every 2 to 4 weeks
Adolescents and Adults who are stable: Monitor PHE monthly
If formal nutritional assessment suggests suboptimal dietary intake or for over reliance on nutritionally incomplete medical foods: Consider monitoring plasma amino acids (full panel), transthyretin, albumin, CBC, ferritin, 25-OH vitamin D, vitamin B12, red blood cell essential fatty acids, trace minerals (copper, selenium, zinc), vitamin A, comprehensive metabolic panel, and folic acid.
Pregnancy Risk Factor
Adverse events have been observed in some animal reproduction studies. High levels of maternal phenylalanine are associated with congenital heart disease, developmental delay, facial dysmorphism, learning difficulties, and microcephaly. Phenylalanine (PHE) concentrations should be normalized prior to conception. Fetal development is optimal when PHE concentrations <360 micromol/L are achieved prior to conception (Vockley, 2014). Dietary control with proper supplementation is recommended during pregnancy. Maternal PHE requirements may change throughout pregnancy; frequent testing and dietary modifications may be necessary (Vockley, 2014). Some clinicians recommend that dietary control be achieved for at least 4 weeks prior to conception; however, studies suggest that as long as control is achieved by 10 weeks of pregnancy, teratogenic effects of untreated maternal phenylketonuria can be decreased (Koch, 2003; Maillot, 2007). In addition to standard fetal monitoring, fetal echocardiography is recommended at 18-22 weeks gestation (Vockley, 2014). Pregnant women exposed to sapropterin are encouraged to enroll in the Kuvan pregnancy registry (866-906-6100).
• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
• Patient may experience headache, diarrhea, rhinorrhea, rhinitis, pharyngitis, or vomiting. Have patient report immediately to prescriber dizziness; black, tarry, or bloody stools; vomiting blood; severe abdominal pain; flushing; wheezing; cough; shortness of breath; severe nausea; severe vomiting; fidgeting; movement disorder; excessive talking; angina; passing out; polyuria; seizures; or swelling of arms or legs (HCAHPS).
• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.
Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.
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- Drug class: miscellaneous metabolic agents
Other brands: Kuvan