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Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
GoodSense Iodine: (30 mL)
Generic: 2% (30 mL, 473 mL, 500 mL, 4000 mL, 20000 mL); 7% (59 mL, 480 mL)
Brand Names: U.S.
- GoodSense Iodine [OTC]
- Antiseptic, Topical
Iodine is required for thyroid hormone synthesis. Iodine is also known to be a powerful broad spectrum germicidal agent effective against a wide range of bacteria, viruses, fungi, protozoa, and spores. Iodosorb® and Iodoflex™ contain iodine in hydrophilic beads of cadexomer which allows a slow release of iodine into the wound and absorption of fluid, bacteria, and other substances from the wound
Topical: Amount absorbed systemically depends upon concentration and characteristics of skin
Primarily trapped by the thyroid
Degraded by amylases normally present in wound fluid
Use: Labeled Indications
Used topically as an antiseptic in the management of minor, superficial skin wounds and has been used to disinfect the skin preoperatively
Hypersensitivity to iodine or any component of the formulation
Iodosorb, Iodoflex: Hashimoto thyroiditis, history of Grave’s disease, or nontoxic nodular goiter; pregnancy; breastfeeding
Cleaning wet ulcers and wounds (Iodosorb, Iodoflex): Topical: Apply to clean wound; maximum: 50 g/application and 150 g/week. Change dressing ~3 times/week; reduce applications as exudate decreases. Do not use for >3 months; discontinue when wound is free of exudate.
Antiseptic for minor cuts, scrapes, burns: Topical: Apply small amount to affected area 1 to 3 times/day
Refer to adult dosing.
Antiseptic for minor cuts, scrapes, burns: Children and Adolescents: Topical: Apply small amount to affected area 1 to 3 times daily
Topical: Iodosorb®: Apply 1/8" to 1/4" thickness to dry sterile gauze, then place prepared gauze onto clean wound. Change dressing when gel changes color from brown to yellow/gray (~3 times/week). Remove with sterile water, saline, or wound cleanser; gently blot fluid from surface leaving wound slightly moist before reapplying gel.
Store at room temperature.
There are no known significant interactions.
Large amounts from excessive absorption may alter thyroid function tests.
Topical: Frequency not defined.
Dermatologic: Eczema, localized erythema
Endocrine & metabolic: Increased thyroid stimulating hormone level
Hypersensitivity: Hypersensitivity reaction
Local: Local irritation, local pain, localized edema
Reactions reported more likely observed following large doses or chronic iodine intoxication; frequency not defined.
Central nervous system: Headache, metallic taste
Dermatologic: Acne vulgaris, skin rash (including ioderma), urticaria
Endocrine & metabolic: Hypothyroidism
Hematologic & oncologic: Adenopathy, eosinophilia, mucous membrane bleeding
Neuromuscular & skeletal: Arthralgia
Ophthalmic: Eyelid edema
Respiratory: Pulmonary edema
• Renal impairment: Use with caution in patients with renal impairment.
Dosage form specific issues:
• Iodosorb: For use as topical application to wet wounds only.
• Appropriate use: Not for application to large areas of the body or for use with tight or air-excluding bandages. When used as a topical antiseptic, improper use may lead to product contamination. Although infrequent, product contamination has been associated with reports of localized and systemic infections. To reduce the risk of infection, ensure antiseptic products are used according to the labeled instructions; avoid diluting products after opening; and apply single-use containers only one time to one patient and discard any unused solution (FDA Drug Safety Communication, 2013).
• OTC labeling: When used for self-medication (OTC), do not use on deep wounds, puncture wounds, animal bites, or serious burns without consulting with health care provider. Notify healthcare provider if condition does not improve within 7 days.
Thyroid function should be monitored in pregnant women, neonates, and young infants if repeat applications over large areas are needed.
An adequate amount of iodine intake is essential for thyroid function. Iodine crosses the placenta and requirements are increased during pregnancy. Iodine deficiency in pregnancy can lead to neurologic damage in the newborn; an extreme form, cretinism, is characterized by gross mental retardation, short stature, deaf mutism, and spasticity. Large amounts of iodine during pregnancy can cause fetal goiter or hyperthyroidism. Transient hypothyroidism in the newborn has also been reported following topical or vaginal use prior to delivery.
• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.
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