Edetate Disodium( EDTA ) Pronouncation: (EH-duh-tate die-SO-dee-uhm)
Class: Cardiovascular agent
- Injection 150 mg/mL
Forms chelates with polyvalent metals, especially calcium, thus increasing their urinary excretion.
The chelate formed is excreted in the urine.
Indications and Usage
Emergency treatment of hypercalcemia; control of ventricular arrhythmias associated with digitalis toxicity.
Dosage and AdministrationAdults
IV 50 mg/kg/day (max 3 g/day). Usually administered in 5 consecutive daily doses followed by 2 days without medication, with repeated courses as needed, for total of 15 doses.
Dissolve 50 mg/kg dose in 500 mL of D5W or sodium chloride 0.9% for injection. Infuse over 3 h or more.Children
IV 40 mg/kg/day (max 70 mg/kg/day) or 15 to 50 mg/kg/day (max 3 g/day) with 5 days between courses.
Dissolve drug in sufficient volume of D5W or sodium chloride 0.9% for injection to bring final concentration to 3% or less. Infuse over 3 h or more.
Do not confuse edetate disodium with edetate calcium disodium.
Store at room temperature.
None well documented.
Laboratory Test Interactions
None well documented.
Transient drop in BP; adverse reactions on myocardial contractility; thrombophlebitis.
Transient circumoral paresthesia; numbness; headache.
Exfoliative dermatitis; toxic skin and mucous membrane reactions.
Nausea; vomiting; diarrhea.
Nephrotoxicity; damage to reticuloendothelial system.
Electrolyte imbalances including hypocalcemia, hypokalemia, and hypomagnesemia; hyperuricemia.
If signs or symptoms of hypocalcemia occur (eg, circumoral numbness/tingling, positive Chvostek's or Trousseau's signs, tetany), notify health care provider.
Category C .
Special Risk Patients
Use drug cautiously in patients with limited cardiac reserve or incipient congestive failure.
Blood sugar and insulin requirements may be lower in insulin-dependent diabetic patients.
Adequately hydrate patient before administration.
Rapid IV infusion or high serum concentrations can cause a precipitous and potentially fatal drop in serum calcium. Do not exceed maximum dose or rate.
Drop in serum calcium.
- Advise patient to remain recumbent for 30 min after infusion because of possibility of orthostatic hypotension.
- Inform patient that breath may be odorous.