Worse Outcomes Seen for Unvaccinated Patients Hospitalized With COVID-19, AKI
WEDNESDAY, June 18, 2025 -- For patients hospitalized with COVID-19 infection and acute kidney injury (AKI), those who are unvaccinated have worse outcomes in terms of kidney function and mortality, according to a study published online June 17 in Kidney Medicine.
Niloofar Nobakht, M.D., from the David Geffen School of Medicine at the University of California Los Angeles, and colleagues conducted a single-center cohort study involving 972 adult patients admitted with COVID-19 infection and AKI from March 1 to March 30, 2022. Of these, 42.3 and 48.0 percent had not received a dose of a U.S.-approved COVID-19 vaccine and had completed the primary vaccine series, respectively.
The researchers found that compared with vaccinated patients, unvaccinated patients had a higher rate of requiring continuous renal replacement therapy (CRRT) during their hospitalization (15.8 versus 10.9 percent). There was a significant association for CRRT during hospitalization with in-hospital death and long-term follow-up death (adjusted hazard ratios, 2.82 and 2.44, respectively). Compared with those who were vaccinated, unvaccinated patients had 2.56-fold higher odds of being discharged on renal replacement therapy. In an adjusted multivariable analysis, significantly increased in-hospital mortality and long-term follow-up mortality were seen for those who were unvaccinated versus those who were vaccinated (adjusted hazard ratios, 5.54 and 4.78, respectively).
"The COVID-19 vaccine is an important intervention that can decrease the chances of developing complications from the COVID-19 infection in patients hospitalized with acute kidney injuries," Nobakht said in a statement.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Further Support and Information on COVID-19
Read this next
Loss of Smell May Linger After COVID-19
WEDNESDAY, Oct. 1, 2025 -- Self-reported change or loss in smell or taste is an accurate signal of verified hyposmia after COVID-19, although there is also a high rate of hyposmia...
Heat May Modify Impact of Toxic Metal(loid)s on Kidney Health
TUESDAY, Sept. 30, 2025 -- Heat may modify the impact of toxic metal(loid)s on kidney health, according to a study published in the Nov. 15 issue of Environmental...
Prevention Strategies Developed for Cardiovascular Manifestations of COVID
FRIDAY, Sept. 26, 2025 -- Prevention strategies for cardiovascular manifestations of acute and long COVID are discussed in a report published online Sept. 18 in the European...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.