Skip to main content

SNP rs13194504 AA Genotype Linked to Severity of Tardive Dyskinesia

Medically reviewed by Carmen Pope, BPharm. Last updated on June 25, 2024.

By Elana Gotkine HealthDay Reporter

TUESDAY, June 25, 2024 -- For patients with schizophrenia, the single-nucleotide polymorphism (SNP) rs13194504 AA genotype is associated with reduced severity of tardive dyskinesia (TD), but is not associated with occurrence, according to a study recently published in Human Psychopharmacology: Clinical & Experimental.

Ruoyu Wang, from the Centre for Addiction and Mental Health in Toronto, and colleagues tested SNPs rs13194504 and rs210133 for the association with the occurrence and severity of TD among 172 patients with schizophrenia who were recruited for four studies at three clinical sites in Canada and the United States.

The researchers found that there was an association for the rs13194504 AA genotype with reduced severity for TD, as measured by the Abnormal Involuntary Movement Scale (AIMS), but not for occurrence of TD. No significant association was seen for rs210133 with either TD occurrence or AIMS scores.

"Our results suggest that the SNP rs13194504 AA genotype may be associated with decreased severity of TD, thus pointing to a potential protective effect against TD," the authors write.

Several authors disclosed ties to the pharmaceutical industry.

Abstract/Full Text

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2025 HealthDay. All rights reserved.

Read this next

Exposure to Maternal Cannabis Use Disorder Ups Risk for Youth Behavioral Disorders

MONDAY, March 24, 2025 -- Children exposed to maternal cannabis use disorder (CUD) during pregnancy and postpartum have an increased risk for later behavioral disorders, according...

Disruptions in Amino Acid, Lipid Metabolism May Signal Tardive Dyskinesia

THURSDAY, March 20, 2025 -- Disruptions in amino acid and lipid metabolism may be biomarkers of tardive dyskinesia (TD), according to a study published online Feb. 21 in...

Behavioral, Developmental Disorders in Children More Common in Recent Years

WEDNESDAY, Feb. 26, 2025 -- The prevalence of children's behavioral and developmental disorders increased nationally from 2019 to 2022, with some conditions linked to caregivers'...

More news resources

Subscribe to our newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.