Risk for Stroke, TIA Increased in Adults With Sickle Cell Disease
By Elana Gotkine HealthDay Reporter
WEDNESDAY, Sept. 25, 2024 -- Adults with sickle cell disease (SCD) have an increased risk for stroke and transient ischemic attack (TIA), according to a study published online Sept. 20 in Blood.
Olubusola Oluwole, M.D., from the University of Pittsburgh, and colleagues determined the cumulative incidence and rates for primary and recurrent strokes and TIAs in people with SCD before and after the STOP trial of 1998, which established chronic transfusions as the standard of care for children with SCD at high risk for stroke. The cohort included 7,636 patients with SCD.
The researchers found that the cumulative incidence was 2.1 and 13.5 percent for first ischemic stroke by age 20 years and by age 60 years, respectively. The corresponding cumulative incidence for first intracranial hemorrhage was 0.5 and 6.8 percent, respectively. Compared with the preceding decade, in 2010 to 2019, there was an increase in ischemic stroke rates in children (younger than 18 years: 234.9 versus 165.1 per 100,000 person-years) and adults (31 to 50 years: 431.1 versus 303.2 per 100,000 person-years). Compared with the previous decade, in 2010 to 2019 the rates of intracranial hemorrhage increased in those aged 18 to 30 years and TIA increased in children younger than 18 years. Older age, hypertension, and hyperlipidemia were risk factors for stroke and TIA.
"As people with SCD live longer, there remains an unmet need to develop guidelines for primary and secondary stroke prevention in adults at highest risk for neurological debility from adverse cerebrovascular events," the authors write.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted September 2024
Read this next
P2Y12 Inhibitor Monotherapy Beneficial for Patients Who Undergo PCI
FRIDAY, June 6, 2025 -- For patients who undergo percutaneous coronary intervention (PCI) and discontinue dual antiplatelet therapy (DAPT), P2Y12 inhibitor monotherapy is...
Longer In-Bed Time Linked to Small Vessel Disease Burden in TIA/Mild Stroke
FRIDAY, May 30, 2025 -- For adult patients with transient ischemic attack (TIA)/mild stroke, disturbed sleep is associated with greater cerebral small vessel disease (SVD) burden...
Intravenous Tenecteplase Beneficial Before Endovascular Thrombectomy
FRIDAY, May 23, 2025 -- For patients with acute ischemic stroke due to large-vessel occlusion who present within 4.5 hours, intravenous tenecteplase before endovascular...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.