Risk of Poor Cardiovascular Outcomes Up in Aging Patients With Down Syndrome
THURSDAY, May 15, 2025 -- Individuals with Down syndrome are at increased risk of poor cardiovascular outcomes, according to a study published online May 7 in the Journal of Internal Medicine.
Annie Pedersen, Ph.D., from the Institute of Biomedicine at the University of Gothenburg in Sweden, and colleagues used national registries to identify 5,155 individuals born in Sweden between 1946 and 2000 with Down syndrome, as well as matched controls (1:50). Cardiovascular risk was compared between the groups.
The researchers found that Down syndrome was associated with increased risk of ischemic stroke (hazard ratio [HR], 4.41) and hemorrhagic stroke (HR, 5.14). Risk of acute myocardial infarction was similar between the groups, overall, but was increased in younger individuals (under 40 years) with Down syndrome. In people with Down syndrome with selected atherosclerotic (HR, 12.67) and embolic (HR, 10.35,) risk factors, risk of ischemic stroke was even higher, compared to controls without risk factors.
"Our results indicate a different spectrum of cardiovascular risk factors in Down syndrome, which might have implications for screening measures as well as primary and secondary prevention strategies," the authors write. "These findings should inform future studies that aim to further investigate the pathophysiological mechanisms of cardiovascular diseases in Down syndrome, as well as health care systems developing guidelines fitted for the unique needs of the Down syndrome population."
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Read this next
Nonoptimal Levels of Traditional Risk Factors Almost Universal Before CVD
MONDAY, Sept. 29, 2025 -- Almost all adults have nonoptimal levels of one or more traditional risk factors before being diagnosed with cardiovascular disease (CVD), according to a...
Prevention Strategies Developed for Cardiovascular Manifestations of COVID
FRIDAY, Sept. 26, 2025 -- Prevention strategies for cardiovascular manifestations of acute and long COVID are discussed in a report published online Sept. 18 in the European...
Cocoa Extract Supplementation Yields Significant Reduction in hsCRP
WEDNESDAY, Sept. 24, 2025 -- Cocoa extract supplementation yields a significant reduction in high-sensitivity C-reactive protein (hsCRP) and an increase in interferon-&gamma...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.