Relative Peripheral Refraction Predicts Myopia Progression in Children
By Elana Gotkine HealthDay Reporter
TUESDAY, June 24, 2025 -- Vertical and horizontal relative peripheral refraction (RPR) are associated with faster axial length progression and higher risk of incident myopia, according to a study published online June 16 in the American Journal of Ophthalmology.
Sander C.M. Kneepkens, M.D., from the Erasmus University Medical Center in Rotterdam, Netherlands, and colleagues used subject-specific ray tracing with magnetic resonance imaging (MRI) to examine the relationship between RPR and myopia in children. Ophthalmological examinations were conducted at age 9 and 13 years, and participants underwent a brain MRI scan at age 9.
The analysis included 1,635 participants, with a distribution of refractive error of 8, 77, and 16 percent for hyperopia, emmetropia, and myopia, respectively. The researchers found that RPR was more hyperopic in those with myopia, with similar results seen for both horizontal and vertical RPR. Both horizontal and vertical RPR were significantly associated with axial length, birth weight, and horizontal retinal radius of curvature, in multivariate linear regression analysis. However, vertical retinal radius of curvature was only associated with vertical RPR. Individuals with faster myopia progression had a higher axial length, lower spherical equivalent, and higher horizontal and vertical RPR. For each diopter increase in horizontal and vertical RPR, the risk of incident myopia increased significantly (odds ratios, 1.40 and 1.29, respectively) after adjustment for covariates including axial length.
"We found that higher RPR is strongly associated with both faster axial length growth and increased risk of developing myopia," the authors write. "Our findings affirm the relevance of RPR in predicting myopia progression and can guide future efforts in developing targeted therapies."
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted June 2025
Read this next
Biomarker Panel Improves Prediction of CKD Progression in Children
TUESDAY, June 24, 2025 -- A biomarker panel can improve prediction of chronic kidney disease (CKD) progression in children, according to a study published in the June issue of the...
Hydrops MRI Accurately Differentiates Meniere Disease, Vestibular Migraine
MONDAY, June 23, 2025 -- The combination of cochlear endolymphatic hydrops (CEH) and vestibular endolymphatic hydrops (VEH) on magnetic resonance imaging (MRI) accurately...
Gluten-Stimulated Interleukin-2 Secretion Useful for Diagnosing Celiac Disease
MONDAY, June 23, 2025 -- Gluten-stimulated interleukin-2 (IL-2) secretion is useful for diagnosis of celiac disease (CeD), according to a study published online June 9 in...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.