Skip to main content

Recommendations Issued for Diagnosing, Managing Gastroparesis

By Elana Gotkine HealthDay Reporter

Posted on September 2025

Medically reviewed by Carmen Pope, BPharm. Last updated on Sep 29, 2025.

via HealthDay

MONDAY, Sept. 29, 2025 -- In a clinical practice guideline issued by the American Gastroenterological Association and published in the October issue of Gastroenterology, conditional recommendations are presented for the diagnosis and management of gastroparesis.

Kyle Staller, M.D., M.P.H., from Massachusetts General Hospital and Harvard Medical School in Boston, and colleagues assessed the evidence and developed recommendations for ensuring an accurate diagnosis and management of patients with idiopathic gastroparesis or gastroparesis related to diabetes.

Twelve recommendations were agreed upon by the guideline panel. For individuals with suspected gastroparesis, a conditional recommendation was made against using two-hour gastric emptying testing and in favor of four-hour testing. Conditional recommendations were made for use of metoclopramide and erythromycin in patients with gastroparesis and against the use of domperidone, prucalopride, aprepitant, nortriptyline, buspirone, and cannabidiol as first-line therapies. In addition, routine use of gastric per-oral endoscopic pyloromyotomy or gastric electrical stimulation is not recommended for patients with gastroparesis; these treatments should be used for select patients with symptoms refractory to medical therapies. There were no recommendations made for use of surgical pyloromyotomy and surgical pyloroplasty.

"These are not hard 'yes' or 'no' rules," Staller said in a statement. "If a treatment is 'suggested against,' it doesn't mean never, since it could still be right for some patients. The goal is for patients and providers to weigh benefits, risks, and personal goals."

Abstract/Full Text

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2025 HealthDay. All rights reserved.

Add as a preferred source on Google Google preffered source badge

More news resources

Subscribe to our newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.