Prevalence of Cirrhosis Higher for Trans- Versus Cisgender Adults
THURSDAY, Dec. 26, 2024 -- Trans- versus cisgender adults have an increased prevalence of cirrhosis but similar five-year survival, according to a study published in the December issue of the American Journal of Gastroenterology.
Hirsh Elhence, from the Keck School of Medicine at the University of Southern California in Los Angeles, and colleagues calculated the age-standardized prevalence of cirrhosis among cisgender versus transgender adults in the Optum deidentified Clinformatics Data Mart Database between 2007 and 2022. For those with diagnoses of incident cirrhosis, age-standardized incidence densities of liver-related outcomes and all-cause mortality were calculated. Using inverse probability treatment weighting, five-year survival was examined.
Overall, 0.07 percent of the 64,615,316 adults were transgender; 0.09 percent of the 329,251 adults with cirrhosis were transgender. The researchers found that the prevalence of cirrhosis was higher for trans- versus cisgender adults (1,285 versus 561 per 100,000). Among those with cirrhosis, trans- versus cisgender adults had higher proportions of anxiety (70.7 versus 43.2 percent), depression (66.4 versus 38.4 percent), HIV/AIDS (8.5 versus 1.6 percent), and alcohol (57.5 versus 51.0 percent) and viral etiologies (30.5 versus 24.2 percent). Similar densities of death, decompensation, and liver transplantation were seen for trans- versus cisgender adults (12.0 versus 14.0, 15.7 versus 14.1, and 0.3 versus 0.3 per 100 person-years, respectively). Transgender and cisgender individuals were found to have similar five-year survival probabilities in an inverse probability treatment weighting survival analysis (63.4 versus 59.1 percent).
"Our findings suggest that transgender individuals represent a vulnerable population that require specific attention from clinicians and researchers alike," the authors write.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Read this next
Worse Emotional Health-Related QoL Seen for Women With Cirrhosis, Ascites
THURSDAY, Aug. 21, 2025 -- Women with cirrhosis and ascites experience worse health-related quality of life (HRQoL) than men, although no difference is seen in daily function...
Prevalence of Alcohol-Related Liver Fibrosis More Than Doubled Over Last 20 Years
MONDAY, July 28, 2025 -- The prevalence of liver fibrosis has more than doubled over the last 20 years among heavy alcohol consumers, according to a research letter published...
Random Forest AI Model Superior for Inpatient Mortality Prognostication in Cirrhosis
THURSDAY, July 24, 2025 -- For inpatients with cirrhosis, a machine learning (ML) model using random forest (RF) analysis is superior for prediction of inpatient mortality...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.