Panel of Biomarkers Can Distinguish Stable, Exacerbation States in COPD
By Elana Gotkine HealthDay Reporter
TUESDAY, Nov. 26, 2024 -- A panel of biomarkers can distinguish between stable and exacerbation states in chronic obstructive pulmonary disease (COPD), and an artificial neural network (ANN) model can predict exacerbations before the occurrence of symptoms, according to a study published online Nov. 20 in ERJ Open Research.
Ahmed J. Yousuf, from the University of Leicester in the United Kingdom, and colleagues measured 35 biomarkers implicated in COPD pathogenesis in paired urine samples from 55 COPD patients during stable and exacerbation states. A model combining the 10 most discriminatory biomarkers was developed as a near-patient dipstick test. This biomarker panel was tested in 105 COPD patients who underwent daily home urine testing over six months. An ANN was developed based on urine biomarkers from 85 of the 105 patients and was tested for predicting exacerbation risk.
The researchers found that the 10-biomarker panel could significantly distinguish exacerbation versus stable state in the discovery and validation studies (receiver operating characteristic with an area under the curve, 0.84 and 0.81, respectively). The ANN model predicted an exacerbation within a 13-day window frame, with an area under the curve of 0.89. Exacerbations were identified at a median of seven days before clinical diagnosis.
"Our findings suggested that the identified urine biomarkers are promising in discriminating COPD exacerbations from stable COPD, can be measured at home with a lateral flow reader and mobile technology and so could be used at scale," the authors write.
Several authors disclosed ties to Mologic, which funded the study.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted November 2024
Read this next
Persistent, New Mucus Plugs Associated With Faster Decline in FEV1 in COPD
WEDNESDAY, May 21, 2025 -- For patients with chronic obstructive pulmonary disease (COPD), persistent and newly formed mucus plugs are associated with a faster decrease in forced...
Mepolizumab Yields Lower Rate of Moderate/Severe Exacerbations in COPD
MONDAY, May 12, 2025 -- For patients with chronic obstructive pulmonary disease (COPD) with a history of exacerbations and a blood eosinophil count of at least 300 cells/µL...
Women Have Higher Risk for COPD Than Men, Regardless of Smoking History
FRIDAY, May 9, 2025 -- Among adults aged 40 years and older, women have an increased risk for chronic obstructive pulmonary disease (COPD), according to a study published online...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.