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One-Hour Glucose on OGTT at Three Months Postpartum Predicts Dysglycemia

Medically reviewed by Carmen Pope, BPharm. Last updated on March 4, 2025.

By Elana Gotkine HealthDay Reporter

TUESDAY, March 4, 2025 -- Higher one-hour blood glucose on an oral glucose tolerance test (OGTT) at three months postpartum can predict the risk for dysglycemia at five years, according to a study published online March 3 in Diabetes Care.

Ravi Retnakaran, M.D., from Mount Sinai Hospital in Toronto, and colleagues compared one-hour and two-hour OGTT measurements at three months postpartum as predictors of dysglycemia during the first five years postpartum. Three hundred sixty-nine women across a range of glucose tolerance in pregnancy underwent multisample two-hour 75-g OGTTs at multiple points postpartum (three months, one year, three years, and five years).

The researchers found that at the three-month OGTT, one-hour glucose identified 60 of 70 women concurrently diagnosed with dysglycemia by two-hour glucose and diagnosed an additional 96 women. There was a progressive increase in the cumulative incidence of dysglycemia over five years by tertile of one-hour glucose on the three-month OGTT. One-hour glucose was the strongest predictor of dysglycemia on regression analyses (change in concordance index [CCI], 16.1 percent), followed by two-hour glucose (change in CCI,14.9 percent). One-hour glucose emerged as the strongest predictor of dysglycemia among women with gestational diabetes mellitus, followed by two-hour glucose (changes in CCI, 13.0 and 12.8 percent, respectively).

"The findings reported herein support consideration of a one-hour OGTT as a potential solution to increase the uptake of postpartum reclassification following hyperglycemia in pregnancy and thereby address a missed opportunity in current clinical practice," the authors write.

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Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

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Posted March 2025

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