Non-Substance-Related Mental Health Disorders Commonly Seen in Overdose Decedents
By Lori Solomon HealthDay Reporter
FRIDAY, Aug. 30, 2024 -- More than one in five people who died of drug overdose in 2022 (21.9 percent) had a reported non-substance-related mental health disorder (MHD), according to research published in the Aug. 29 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.
Amanda T. Dinwiddie, M.P.H., from the CDC in Atlanta, and colleagues used data from the CDC State Unintentional Drug Overdose Reporting System to describe characteristics of persons in 43 states and the District of Columbia who died of unintentional or undetermined-intent drug overdose and had any MHD.
The researchers found that in 2022, 21.9 percent of persons who died of drug overdose had a reported MHD, including most frequently depressive (12.9 percent), anxiety (9.4 percent), and bipolar (5.9 percent) disorders. Eight in 10 overdose deaths involved opioids, primarily illegally manufactured fentanyls. Compared with those without an MHD, higher proportions of deaths among decedents with an MHD involved antidepressants and benzodiazepines (no MHD: 3.3 and 8.5 percent, respectively; with MHD: 9.7 and 15.3 percent, respectively). Nearly one fourth of decedents with an MHD had at least one recent (within one month of death) potential opportunity for intervention (e.g., about one in 10 were undergoing substance use disorder treatment and one in 10 visited an emergency department or urgent care facility).
"Expanding efforts to identify and address co-occurring mental health and substance use disorders (e.g., integrated screening and treatment) and strengthen treatment retention and harm reduction services could save lives," the authors write.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2025 HealthDay. All rights reserved.
Posted August 2024
Read this next
Buprenorphine for Opioid Use Disorder in Pregnancy Can Improve Outcomes
FRIDAY, May 2, 2025 -- For mothers with opioid use disorder (OUD), treatment with buprenorphine in pregnancy is associated with improved maternal and infant outcomes, according to...
Mental Health, Neurodevelopmental Diagnoses in Publicly Insured Children on the Rise
WEDNESDAY, April 30, 2025 -- The percentage of publicly insured children receiving any mental health or neurodevelopmental disorder diagnosis significantly increased between 2010...
Risky Health Behaviors Tied to Poorer Mental Well-Being, General Health in Midlife
MONDAY, April 28, 2025 -- Risky health behaviors, both current and cumulatively over time, are associated with poorer mental well-being and self-reported health, according to a...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.