No Link Seen Between Preop GLP-1 Receptor Agonist Use and Postop Aspiration Pneumonia
THURSDAY, March 6, 2025 -- Preoperative glucagon-like peptide-1 receptor agonist (GLP-1 RA) use is not associated with short-term postoperative aspiration pneumonia, according to a study published online March 4 in JAMA Network Open.
Yuan-Hsin Chen, M.D., M.P.H., from Massachusetts General Hospital in Boston, and colleagues conducted a retrospective cohort study to examine whether preoperative GLP-1 RA use is associated with postoperative aspiration pneumonia among adult patients undergoing one of 14 common surgical procedures from April 1, 2020, to Sept. 30, 2022. The study included 366,476 patients; 1.6 percent had a preoperative prescription for GLP-1 RA.
The researchers found that compared with nonusers, patients using GLP-1 RAs were more likely to be female (59.0 versus 56.4 percent) and diagnosed with both obesity and diabetes (47.5 versus 6.8 percent). No significant differences were seen in the odds of postoperative pneumonia between GLP-1 RA users and nonusers in an adjusted analysis (odds ratio, 0.78; 95 percent confidence interval, 0.57 to 1.06; P = 0.12).
"In this cohort study, we found no significant association between GLP-1 RA use and increased short-term postoperative aspiration pneumonia," the authors write. "This finding suggests that it may be beneficial to reassess the preoperative withholding guidelines for GLP-1 RAs."
One author disclosed ties to the pharmaceutical industry.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Read this next
Lung Cancer Screening Beneficial to Age 80 for Candidates Fit for Surgery
FRIDAY, Sept. 12, 2025 -- People aged 75 to 80 years at last screen who are diagnosed with screen-detected lung cancer (LC) have lower overall survival, but those undergoing...
No Adverse Neurodevelopmental Effects Seen From Inhaled Anesthesia in Children Under 2
THURSDAY, Sept. 11, 2025 -- For children younger than 2 years undergoing surgery, no adverse neurodevelopmental effects are seen with the addition of dexmedetomidine and...
Complication Risk Top Concern for African American Women Undergoing Breast Reconstruction
TUESDAY, Sept. 9, 2025 -- For African American patients undergoing mastectomy, the risk for complications and additional surgeries are the top concerns driving breast...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.