No Link Found Between COVID-19 Vaccination During Pregnancy and Spontaneous Abortion
By Lori Solomon HealthDay Reporter
THURSDAY, May 15, 2025 -- There is no association between COVID-19 vaccination in pregnancy and spontaneous abortion, according to a study published online May 2 in Obstetrics & Gynecology.
Sangini S. Sheth, M.D., from the Yale School of Medicine in New Haven, Connecticut, and colleagues examined the association between COVID-19 vaccination and spontaneous abortion. Analysis included patients aged 16 to 49 years with singleton pregnancies, one or more prenatal visits, and continuous health plan enrollment. Those with spontaneous abortion (296; between 6 and less than 20 weeks of gestation) were matched with 592 live births between Jan. 19, 2021, and Oct. 27, 2021.
The researchers found that there was no association between spontaneous abortion and COVID-19 vaccination (adjusted odds ratio [aOR], 0.85; 95 percent confidence interval [CI], 0.56 to 1.30). Similarly, there was no association between spontaneous abortion and dose number versus no vaccine (one dose: aOR, 0.81; 95 percent CI, 0.39 to 1.70; two doses: aOR, 0.84; 95 percent CI, 0.51 to 1.38; vaccine manufacturer: Moderna aOR, 0.59 [95 percent CI, 0.29 to 1.19], Pfizer-BioNTech aOR, 0.97 [95 percent CI, 0.57 to 1.66]). Lastly, there was no association for vaccine exposure window of six weeks before spontaneous abortion or index date (aOR, 0.87; 95 percent CI, 0.53 to 1.44).
"This is a rigorously conducted study that continues to show that the COVID-19 vaccines are safe during pregnancy," Sheth said in a statement. "For women who are early in pregnancy or those who are thinking about getting pregnant, given the risks of COVID-19 disease, they should feel encouraged to go ahead and get vaccinated if they are not already."
Several authors disclosed ties to the pharmaceutical industry.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted May 2025
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