No Infections Seen After Transperineal Biopsy for Prostate Cancer
MONDAY, Sept. 30, 2024 -- For patients with suspicion for prostate cancer, transperineal biopsy has similar cancer detection rates as transrectal biopsy but a significantly lower risk for infection, according to a research letter published online Sept. 19 in JAMA Oncology.
Jim C. Hu, M.D., M.P.H., from the New York Presbyterian Weill Cornell Medicine Hospital in New York City, and colleagues randomly assigned patients with suspicion for prostate cancer to clinic-based transperineal biopsy (without antibiotic prophylaxis) or transrectal biopsy (with targeted prophylaxis). A total of 875 patients were randomly assigned from February 2021 through March 2024; 372 and 370 underwent biopsy in the transperineal and transrectal groups, respectively.
The researchers found no infections in the transperineal group versus six infections in the transrectal group in an intent-to-treat analysis (difference, −1.6 percent). Low and similar rates of other complications were seen. Overall, 55 and 52 percent of patients in the transperineal and transrectal groups, respectively, had high-grade cancer (difference, 2.9 percent).
"Transperineal biopsy significantly lowers the risk of infectious complications versus transrectal biopsy," the authors write. "Transperineal biopsy should be the standard of care for prostate biopsy."
One author disclosed financial ties to Perineologic and KOELIS.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Read this next
Higher Tattoo Exposure Linked to Reduced Melanoma Risk
MONDAY, Sept. 29, 2025 -- Higher tattoo exposure may be associated with reduced melanoma risk, according to a study published online Aug. 21 in the Journal of the National Cancer...
Antithymocyte Globulin Cuts Loss of β-Cell Function in Type 1 Diabetes
MONDAY, Sept. 29, 2025 -- Antithymocyte globulin (ATG) 2.5 and 0.5 mg/kg reduces loss of β-cell function in young people with recent-onset type 1 diabetes, according to a...
Loss of Therapeutic Benefit Seen After Stopping Baricitinib in Type 1 Diabetes
MONDAY, Sept. 29, 2025 -- Two-year follow-up shows a loss of therapeutic benefit when baricitinib treatment is stopped in type 1 diabetes (T1D), according to a study presented at...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.