Neoantigen DNA Vaccines Safe, Induce Response in Triple-Negative Breast Cancer
THURSDAY, Nov. 14, 2024 -- Neoantigen DNA vaccines are safe and capable of inducing neoantigen-specific immune responses in patients with triple-negative breast cancer, according to a study published online Nov. 14 in Genome Medicine.
Xiuli Zhang, M.D., from the Washington University School of Medicine in St. Louis, and colleagues developed a neoantigen DNA vaccine platform capable of presenting human leukocyte antigen class I and II epitopes. Tumor/normal exome sequencing and tumor RNA sequencing were used to identify expressed somatic mutations; cancer neoantigens were identified and prioritized using neoantigen prediction algorithms in order to facilitate vaccine design. The neoadjuvant DNA vaccines were administered in the adjuvant setting in a phase 1 clinical trial involving triple-negative breast cancer patients with persistent disease on surgical pathology following neoadjuvant chemotherapy. Vaccines were monitored for safety and immune responses.
Overall, 18 patients received three doses of a neoantigen DNA vaccine encoding 11 neoantigens on average per patient. The researchers found that the vaccines were well tolerated, with few adverse events reported. Fourteen of the patients had neoantigen-specific T-cell responses. In the cohort of vaccinated patients, recurrence-free survival was 87.5 percent at a median follow-up of 36 months.
"These results support further study of the neoantigen DNA vaccine platform in triple-negative breast cancer and other low mutation burden cancers," the authors write.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Read this next
Hepatitis B Virus Immunity Linked to Reduced Risk for Diabetes
THURSDAY, Sept. 11, 2025 -- Hepatitis B virus (HBV) immunity in individuals without HBV infection is associated with a reduced risk for diabetes, according to a study published...
Complication Risk Top Concern for African American Women Undergoing Breast Reconstruction
TUESDAY, Sept. 9, 2025 -- For African American patients undergoing mastectomy, the risk for complications and additional surgeries are the top concerns driving breast...
Risk for Second Cancer Low for Women Treated for Early, Invasive Breast Cancer
THURSDAY, Sept. 4, 2025 -- The risk for second primary cancers is higher for breast cancer survivors than for women in the general population; however, the risk remains low and is...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.