Skip to main content

Molecular Residual Disease Analysis May Predict Disease Recurrence After Lung Cancer Resection

Medically reviewed by Carmen Pope, BPharm. Last updated on March 25, 2025.

By Elana Gotkine HealthDay Reporter

TUESDAY, March 25, 2025 -- For patients with resected stage IB-IIIA epidermal growth factor receptor-mutated non-small cell lung cancer, molecular residual disease (MRD) precedes disease-free survival (DFS) events in patients receiving osimertinib treatment or placebo and can be used to predict disease recurrence, according to a study published online March 17 in Nature Medicine.

Roy S. Herbst, M.D., Ph.D., from Yale School of Medicine and Yale Cancer Center in New Haven, Connecticut, and colleagues examined whether tumor-informed, circulating tumor DNA-based MRD could predict recurrence in a post-hoc analysis of 220 patients from the phase 3 ADAURA trial (112 received osimertinib; 108 received placebo).

The researchers found that MRD preceded imaging DFS events by a median of 4.7 months in this study. At 36 months, the DFS and MRD event-free rate was 86 versus 36 percent for patients in the osimertinib and placebo groups (hazard ratio, 0.23). DFS or MRD events were detected in 25 percent of patients (28 patients) in the osimertinib group; most events occurred after cessation of osimertinib (19 of 28 events; 68 percent) and within 12 months of stopping osimertinib (11 of 19 events; 58 percent). The DFS and MRD event-free rate was 66 percent at 24 months after osimertinib.

"Plasma-based, tumor-informed MRD analysis may predict disease recurrence during adjuvant treatment and during posttreatment follow-up," the authors write. "MRD monitoring may inform clinical intervention, including restarting or intensifying treatment."

Several authors disclosed ties to the biopharmaceutical industry.

Abstract/Full Text

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2025 HealthDay. All rights reserved.

Read this next

Study IDs Predictors of Biomechanical Function in Patients With OA Undergoing Hip Replacement

WEDNESDAY, April 23, 2025 -- For patients undergoing total hip arthroplasty (THA), osteoarthritis (OA) severity is the best predictor of preoperative biomechanical function, and...

Durable Disease Control Possible After Stopping Immune Checkpoint Inhibitors in NSCLC

TUESDAY, April 22, 2025 -- Prolonged disease control can be maintained for patients with advanced non-small cell lung cancer (NSCLC) who discontinue immune checkpoint inhibitors...

Breast, Colorectal Cancer Screening Higher Than Lung Cancer Screening

TUESDAY, April 15, 2025 -- Among individuals eligible for lung cancer screening (LCS), use of breast cancer screening (BCS) and colorectal cancer screening (CCS) is much higher...

More news resources

Subscribe to our newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.