Menopausal Symptom Burden Tied to Cognitive, Behavioral Impairment
By Lori Solomon HealthDay Reporter
MONDAY, March 17, 2025 -- Higher menopausal symptom burden is associated with poorer cognitive and behavioral impairment later in life, according to a study published online March 5 in PLOS ONE.
Jasper F.E. Crockford, from the University of Calgary in Alberta, Canada, and colleagues investigated the association between menopausal symptoms and cognitive and behavioral changes. Analysis included 896 postmenopausal female participants.
The researchers found that greater menopausal symptom burden was associated with higher Everyday Cognition (ECog-II) Scale total scores (b = 5.37; 95 percent confidence interval, 2.85 to 7.97) and higher Mild Behavioral Impairment Checklist (MBI-C) total scores (b = 6.09; 95 percent confidence interval, 2.50 to 9.80). While hormone therapy was not significantly associated with ECog-II total scores (b = −10.98; 95 percent confidence interval, −25.33 to 6.35), hormone therapy was significantly associated with lower MBIC total scores (b = −26.90; 95 percent confidence interval,−43.35 to −5.67).
"Menopausal symptom burden is associated with poorer cognitive function and more mild behavioral impairment symptoms in mid- to late-life. Hormone therapy may help mitigate symptoms of mild behavioral impairment," the authors write. "These findings suggest that the experience of menopause may indicate susceptibility to cognitive and behavioral changes, both markers of dementia."
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2025 HealthDay. All rights reserved.
Posted March 2025
Read this next
Intensive BP Reduction Effective for Lowering All-Cause Dementia Risk
TUESDAY, April 29, 2025 -- An intensive blood pressure (BP) reduction intervention is effective for lowering the risk for all-cause dementia among individuals aged 40 years and...
32 Percent of Dementia Attributed to Audiometric Hearing Loss
MONDAY, April 28, 2025 -- The population attributable fraction of dementia from any audiometric hearing loss is 32.0 percent, according to a study published online April 17 in...
Moderately Preterm Birth Tied to Long-Term Cognitive Problems
FRIDAY, April 25, 2025 -- Moderately preterm birth is associated with cognitive problems at ages 9 to 10 years, according to a study published online April 14 in JAMA Network...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.