Skip to main content

Medetomidine, a Pet Sedative, Spreads in U.S. Illegal Drug Supply

Medically reviewed by Carmen Pope, BPharm. Last updated on May 2, 2025.

By I. Edwards HealthDay Reporter

FRIDAY, May 2, 2025 — A sedative used in animals is showing up more often in illegal drugs and may be making opioid overdoses harder to treat, U.S. health officials warn.

The drug, called medetomidine, is used by veterinarians to sedate pets. It's similar to xylazine, another animal drug that has already made the U.S. opioid crisis worse, The Associated Press reported.

Now, medetomidine is being found mixed with fentanyl and other street drugs, the U.S. Centers for Disease Control and Prevention (CDC) stated.

The CDC released three reports showing how the drug is spreading in cities like Chicago, Philadelphia and Pittsburgh.

In Chicago last May, officials noticed a spike in overdoses. Naloxone, the usual treatment for fentanyl overdose, wasn’t working well.

After an investigation, 12 cases were confirmed to involve medetomidine, and more than 160 others were considered likely cases, including one possible death.

In Philadelphia, medetomidine was found in 72% of illegal opioid samples tested late last year, AP reported.

That was more than xylazine, which had been a growing concern in recent years.

More than 160 people in the city were hospitalized with a strange kind of withdrawal that did not respond to usual treatments. But doctors found that another medication, dexmedetomidine, worked.

Pittsburgh also saw 10 similar cases around the same time.

Sources

  • The Associated Press, May 1, 2025

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2025 HealthDay. All rights reserved.

Read this next

Fentanyl Fueling OD Deaths Among Teens, Young Adults

TUESDAY, May 27, 2025 — The powerful synthetic opioid fentanyl is involved in most fatal drug overdoses (OD) among teens and young adults, a new study says. Worse, fentanyl...

Trump's Surgeon General Pick Touts Psychedelics for Health

THURSDAY, May 15, 2025 — President Donald Trump's choice for U.S. surgeon general has raised eyebrows for promoting the use of psychedelic drugs, such as psilocybin, in a...

CDC: Drug Overdose Deaths Down More Than 25 Percent in 2024

WEDNESDAY, May 14, 2025 -- Drug overdose deaths decreased by 26.9 percent from 2023 to 2024, according to provisional data released today from the National Center for Health...

More news resources

Subscribe to our newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.