Measles Cases in England Consistent With Waning of Vaccine Immunity
By Elana Gotkine HealthDay Reporter
MONDAY, Sept. 30, 2024 -- Measles cases in England are consistent with the waning of vaccine-induced immunity, according to a study published online Sept. 26 in The Lancet Public Health.
Alexis Robert, Ph.D., from the London School of Hygiene & Tropical Medicine, and colleagues examined whether measles dynamics observed in England between 2010 and 2019 were in line with waning of vaccine-induced immunity using a compartmental mathematical model stratified by age group, region, and vaccine status. The deterministic model was fitted under three scenarios: without waning of vaccine-induced immunity, with waning depending on time since vaccination, and with waning depending on time since vaccination starting in 2000.
The researchers found that the number of one-dose recipients among measles cases was overestimated in the scenario without waning, and the number of two-dose recipients was underestimated among cases older than 15 years (median, 75 cases in simulations without waning; 196 cases in simulations with waning; 188 cases in simulations when waning started in 2000; and 202 observed cases). The number of onward transmissions from vaccinated cases was 83 percent of transmissions from unvaccinated cases. There was a slow estimated waning rate (0.039 percent per year of age), but this was sufficient to increase the burden of measles.
"The waning of vaccine-induced immunity likely explains the observed dynamics and age distribution of vaccinated measles cases in England between 2010 and 2019," the authors write. "Many near-elimination countries have reported decreased vaccine coverage since 2020, leading to an increase in measles incidence in Europe in 2023."
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted September 2024
Read this next
No Link Found Between COVID-19 Vaccination During Pregnancy and Spontaneous Abortion
THURSDAY, May 15, 2025 -- There is no association between COVID-19 vaccination in pregnancy and spontaneous abortion, according to a study published online May 2...
RSV Vaccines, Nirsevimab Tied to Reduced RSV-Linked Hospitalization
TUESDAY, May 13, 2025 -- Maternal respiratory syncytial virus (RSV) vaccination and nirsevimab were associated with a reduction in RSV-associated hospitalization rates among...
Combined Flu, SARS-CoV-2 Vaccine as Effective as Individual Vaccines for Older Adults
FRIDAY, May 9, 2025 -- mRNA-1083 vaccine is noninferior and induces higher immune responses than recommended influenza and COVID-19 vaccines against several influenza strains and...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.