Intravenous Tenecteplase Beneficial Before Endovascular Thrombectomy
By Elana Gotkine HealthDay Reporter
FRIDAY, May 23, 2025 -- For patients with acute ischemic stroke due to large-vessel occlusion who present within 4.5 hours, intravenous tenecteplase before endovascular thrombectomy is associated with higher functional independence at 90 days, according to a study published online May 21 in the New England Journal of Medicine to coincide with the annual European Stroke Organisation Conference, held from May 21 to 23 in Helsinki.
Zhongming Qiu, M.D., from the Second Affiliated Hospital of Army Medical University in Chongqing, China, and colleagues conducted an open-label trial in China involving patients with acute ischemic stroke due to large-vessel occlusion who presented within 4.5 hours after onset and were eligible for thrombolysis. Participants were randomly assigned to receive either intravenous tenecteplase followed by endovascular thrombectomy or endovascular thrombectomy alone (278 and 272 patients, respectively). The primary outcome was functional independence (a score of 0 to 2 on the modified Rankin scale, with higher scores indicating more severe disability) at 90 days.
The researchers found that 52.9 and 44.1 percent of patients in the tenecteplase-thrombectomy group and the thrombectomy-alone group, respectively, had functional independence at 90 days (unadjusted risk ratio, 1.20). Overall, 6.1 and 1.1 percent of patients, respectively, in the tenecteplase-thrombectomy group and the thrombectomy-alone group had successful reperfusion before thrombectomy, while 91.4 and 94.1 percent, respectively, had successful reperfusion after thrombectomy. Symptomatic intracranial hemorrhage within 48 hours occurred in 8.5 and 6.7 percent of patients, respectively, in the tenecteplase-thrombectomy group and the thrombectomy-alone group; mortality at 90 days was 22.3 and 19.9 percent, respectively.
"The lack of a consistent significant benefit across secondary outcomes makes this finding tenuous," the authors write.
The study was funded in part by China Shijiazhuang Pharmaceutical Company Recomgen Pharmaceutical.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted May 2025
Read this next
Acute Ischemic Stroke Up in Native Hawaiian, Pacific Islander People
FRIDAY, Sept. 5, 2025 -- The incidence of acute ischemic stroke (AIS) is higher among Native Hawaiian or Pacific Islander (NHOPI) individuals than among other racial and ethnic...
Use of Vaginal Estradiol Tablets Not Linked to Recurrent Stroke
THURSDAY, Aug. 21, 2025 -- For women with a history of ischemic stroke, use of vaginal estradiol tablets is not associated with an increased rate of recurrent stroke, according to...
Seniors With Certain Cardiovascular Diseases Saw Life's Essential 8 Scores Decline 2013 to 2018
WEDNESDAY, Aug. 20, 2025 -- From 2013 to 2018, older adults with heart failure, stroke, and hypertension experienced significant declines in Life's Essential 8 (LE8) scores...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.