Individuals With Advanced Breast Cancer at Diagnosis More Likely to Have CVD
By Elana Gotkine HealthDay Reporter
MONDAY, Jan. 6, 2025 -- Individuals with advanced breast cancer at diagnosis are more likely to have prevalent cardiovascular disease (CVD), according to a study published online Jan. 2 in JAMA Network Open.
In a population-based case-control study, Ivan Angelov, from the University of Texas MD Anderson Cancer Center in Houston, and colleagues examined whether female patients aged at least 66 years presenting with advanced breast cancers are more likely to have prevalent CVD compared with those with early-stage breast cancer at the time of diagnosis.
The full analytic cohort included 19,292 matched female patients; 9,478 had prevalent CVD. The researchers found that the odds of prevalent CVD were significantly increased in individuals with locally advanced or metastatic cancer at diagnosis in propensity score-matched, multivariable-adjusted models (odds ratio, 1.10; 95 percent confidence interval, 1.03 to 1.17; P = 0.007). This association was seen for hormone receptor-positive breast cancer (odds ratio, 1.11; 95 percent confidence interval, 1.03 to 1.19; P = 0.006), but not hormone receptor-negative (odds ratio, 1.02; 95 percent confidence interval, 0.86 to 1.21; P = 0.83). When examining locally advanced and metastatic disease separately, odds ratios were directionally consistent (odds ratios [95 percent confidence intervals], 1.09 [1.02 to 1.17; P = 0.02] and 1.20 [0.94 to 1.54; P = 0.15], respectively) among all receptor subtypes.
"This retrospective case-control study found an association between prevalent CVD and more advanced stage of breast cancer at diagnosis, independent of factors associated with delayed diagnosis and shared risk," the authors write.
One author disclosed ties to Artidis Research, Varian Medical Systems, and Oncora Medical.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted January 2025
Read this next
Declining Childhood Vaccination May Increase Risk for Vaccine-Preventable Infections
WEDNESDAY, April 30, 2025 -- Declining childhood vaccination rates may increase outbreaks of eliminated vaccine-preventable infections within the United States, leading to a...
AACR: Incidence-Based Mortality Dropping for Young Women With Breast Cancer
TUESDAY, April 29, 2025 -- Incidence-based mortality (IBM) declined from 2010 to 2020 among women aged 20 to 49 years diagnosed with breast cancer, according to a study presented...
AACR: Nonsurgical Treatment Feasible for Mismatch Repair-Deficient Tumors
TUESDAY, April 29, 2025 -- A neoadjuvant programmed cell death 1 (PD-1) blockade enables nonoperative management among patients with early-stage mismatch repair-deficient (dMMR)...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.