Increasing Exercise in Midlife Aids Brain Health
By Lori Solomon HealthDay Reporter
TUESDAY, May 6, 2025 -- Boosting physical activity in midlife may improve brain health, according to a study published online April 30 in Alzheimer's & Dementia.
Muge Akinci, Ph.D., from the Barcelona Institute for Global Health in Spain, and colleagues investigated midlife physical activity changes in relation to Alzheimer disease-related pathologies. The analysis included 337 cognitively unimpaired adults with baseline and follow-up physical activity evaluations within 4.07 years.
The researchers found that remaining sedentary was associated with lower cortical thickness versus doing limited physical activity, maintaining adherence, or becoming adherent to World Health Organization recommendations. Becoming adherent to recommendations was associated with lower amyloid burden versus becoming nonadherent. There was a dose-dependent association between increased activity amounts and lower amyloid burden.
"These results support the beneficial effect of physical activity and new adherence to the World Health Organization recommendations from the standpoint of Alzheimer disease prevention, and call for interventions to promote physical activity increases in middle-aged adults in preclinical Alzheimer disease," the authors write.
Several authors disclosed ties to the pharmaceutical industry.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted May 2025
Read this next
Centenarians Have Fewer Diseases, Develop Them More Slowly
FRIDAY, Aug. 15, 2025 -- Centenarians have lower overall disease burden, delayed onset of multiple conditions, and fewer cooccurring diseases over time, according to a study...
Opportunistic Community Screening IDs Uncontrolled Cardiovascular Risk Factors
FRIDAY, Aug. 15, 2025 -- Opportunistic pop-up community screening identifies a high prevalence of uncontrolled cardiovascular risk factors, according to a study published online...
Missed Opportunity Common in Patients With High-Grade Serous Ovarian Cancer
FRIDAY, Aug. 15, 2025 -- A considerable proportion of patients with high-grade serous cancer (HGSC) have missed opportunities for risk assessment with genetic testing and for...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.