Incidence Rates of Appendiceal Adenocarcinoma Increasing
By Elana Gotkine HealthDay Reporter
MONDAY, June 16, 2025 -- The incidence rates of appendiceal adenocarcinoma (AA) increased after 1945, according to a study published online June 10 in the Annals of Internal Medicine.
Andreana N. Holowatyj, Ph.D., from Vanderbilt University Medical Center in Nashville, Tennessee, and colleagues estimated the incidence rates of AA across birth cohorts in the United States in a retrospective cohort study. The study included 4,858 persons aged 20 years or older when diagnosed with pathologically confirmed primary AA (nonmucinous, mucinous, goblet cell, or signet ring cell carcinoma) from 1975 to 2019. Twenty-one overlapping birth cohorts were created using five-year age groups and time periods (1891-1899 to 1991-1999).
The researchers found that among the 1980 birth cohort, the incidence rates of AA more than tripled (incidence rate ratio [IRR], 3.41), while they quadrupled among the 1985 birth cohort (IRR, 4.62) compared with the 1945 birth cohort. Across successive birth cohorts, age-specific incidence rates of AA increased after 1945 for all tumor histological types, although to varying degrees.
"The current absence of appendiceal cancer prevention and screening methods emphasizes the importance of efforts to support earlier detection in a rare cancer where clinical trials have been historically very limited," the authors write.
Two authors disclosed ties to the pharmaceutical and biotechnology industries.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted June 2025
Read this next
CT Colonography Cost-Effective, Clinically Effective for CRC Screening
MONDAY, June 16, 2025 -- Computed tomography colonography (CTC) is cost-effective and clinically effective for colorectal cancer (CRC) screening, according to a study published...
Doctors' Preferences for Their Own End-of-Life Care? No Life-Sustaining Practices
FRIDAY, June 13, 2025 -- Many physicians would personally prefer to avoid life-sustaining practices if they had advanced cancer or Alzheimer disease, according to a study...
Circulating Tumor DNA Can Be Detected Several Years Before Cancer Diagnosis
FRIDAY, June 13, 2025 -- Circulating tumor DNA can be detected more than three years prior to a clinical cancer diagnosis, according to a research brief published online May 22 in...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.