Hormone Tx Tied to Reductions in Insulin Resistance
By Lori Solomon HealthDay Reporter
WEDNESDAY, Sept. 11, 2024 -- Hormone therapy (HT) is associated with significantly reduced insulin resistance in healthy postmenopausal women, according to a study presented at the annual meeting of the Menopause Society, held from Sept. 10 to 14 in Chicago.
Tanya Li, from Reading Hospital Tower Health in West Reading, Pennsylvania, and colleagues conducted a systematic literature review to identify randomized controlled trials (1998 to 2024) that evaluated the effect of HT on insulin resistance, measured by the homeostasis model assessment of insulin resistance (HOMA-IR), in postmenopausal women without diabetes, hypertension, or cardiovascular diseases.
Based on pooled data from 17 included trials (29,287 postmenopausal women), the researchers found the HOMA-IR was significantly reduced in women who received HT (overall effect: raw mean difference [RMD], −0.24; P < 0.001; I2 = 60.3 percent) compared with those who received placebo. The HOMA-IR was significantly reduced in both women who received estrogen alone (RMD = −0.42; P < 0.001) and those who received estrogen plus progestogen (RMD = −0.14; P = 0.005) versus those who received placebo.
“Our analysis showed that both types of hormone therapy, including oral and transdermal routes, significantly reduced insulin resistance in healthy postmenopausal women, although estrogen alone was associated with a more prominent reduction when compared to a combination hormone therapy," lead researcher Xuezhi Jiang, M.D., also from Reading Hospital Tower Health, said in a statement.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted September 2024
Read this next
Air Pollution May Worsen Bone Health in Postmenopausal Women
FRIDAY, May 16, 2025 -- Exposure to air pollution may worsen bone loss in postmenopausal women, according to a study published online April 24 in the Journal of Bone and...
More Research Needed to Prepare People With Mental Illness for Menopause
THURSDAY, May 15, 2025 -- Few studies examine how people living with a mental illness may be best prepared for the menopause transition, considering both menopause symptoms and...
Hormone Therapy Tied to Worse Bladder Health in Postmenopausal Women
TUESDAY, May 6, 2025 -- Hormone therapy use is linked to worse bladder health in postmenopausal women, according to a study published online April 29 in Menopause. Camille...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.