Hormone Tx Tied to Reductions in Insulin Resistance
WEDNESDAY, Sept. 11, 2024 -- Hormone therapy (HT) is associated with significantly reduced insulin resistance in healthy postmenopausal women, according to a study presented at the annual meeting of the Menopause Society, held from Sept. 10 to 14 in Chicago.
Tanya Li, from Reading Hospital Tower Health in West Reading, Pennsylvania, and colleagues conducted a systematic literature review to identify randomized controlled trials (1998 to 2024) that evaluated the effect of HT on insulin resistance, measured by the homeostasis model assessment of insulin resistance (HOMA-IR), in postmenopausal women without diabetes, hypertension, or cardiovascular diseases.
Based on pooled data from 17 included trials (29,287 postmenopausal women), the researchers found the HOMA-IR was significantly reduced in women who received HT (overall effect: raw mean difference [RMD], −0.24; P < 0.001; I2 = 60.3 percent) compared with those who received placebo. The HOMA-IR was significantly reduced in both women who received estrogen alone (RMD = −0.42; P < 0.001) and those who received estrogen plus progestogen (RMD = −0.14; P = 0.005) versus those who received placebo.
“Our analysis showed that both types of hormone therapy, including oral and transdermal routes, significantly reduced insulin resistance in healthy postmenopausal women, although estrogen alone was associated with a more prominent reduction when compared to a combination hormone therapy," lead researcher Xuezhi Jiang, M.D., also from Reading Hospital Tower Health, said in a statement.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Read this next
Type of Hormone Therapy Used After Menopause Affects Memory Performance
FRIDAY, Aug. 29, 2025 -- Earlier age at menopause is associated with lower scores on all cognitive domains, and menopausal hormone therapy (MHT) differentially affects cognition...
Rate of Sexual Dysfunction Similar in Middle-Aged, Older Women
MONDAY, Aug. 18, 2025 -- Older women experience female sexual dysfunction (FSD) at similar rates as midlife women but report less sexual distress, according to a study published...
Increasing Sit-to-Stand Transitions Lowers BP in Postmenopausal Women
FRIDAY, Aug. 8, 2025 -- Changing sedentary behaviors is feasible for postmenopausal women with overweight and obesity, and increasing sit-to-stand transitions (STSTs) is...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.