Higher Heathy Eating Index Score Beneficial in Prostate Cancer
By Elana Gotkine HealthDay Reporter
THURSDAY, Oct. 24, 2024 -- Higher adherence to American dietary guideline recommendations may be associated with a lower risk for grade reclassification in men diagnosed with grade group 1 (GG1) prostate cancer, according to a study published online Oct. 17 in JAMA Oncology.
Zhou Tony Su, M.D., from the Johns Hopkins University School of Medicine in Baltimore, and colleagues conducted a prospective cohort study involving men diagnosed with GG1 prostate cancer from January 2005 to February 2017 who were undergoing active surveillance. The association of the baseline Healthy Eating Index 1999 to 2000 (HEI) and energy-adjusted HEI (E-HEI), Dietary Inflammatory Index (DII), and energy-adjusted DII (E-DII) scores with grade reclassification to GG2 or greater or GG3 or greater was examined.
Data were included for 886 men. The researchers found that 21 percent of the men had grade reclassification to GG2 or greater after a median follow-up of 6.5 years, including 6 percent with extreme grade reclassification. The cumulative incidence of grade reclassification was 7, 15, and 33 percent at three, five, and 10 years, respectively; the corresponding values for extreme grade reclassification were 2, 4, and 10 percent. Higher baseline HEI and E-HEI per one-standard deviation increase in score were associated with a significantly lower risk for grade reclassification (subhazard ratios [95 percent confidence intervals], 0.85 [0.73 to 0.98] and 0.86 [0.74 to 1.00], respectively) and extreme grade reclassification (subhazard ratios [95 percent confidence intervals], 0.72 [0.57 to 0.93] and 0.73 [0.57 to 0.94], respectively). Neither baseline DII nor E-DII were associated with either grade reclassification outcome.
"Our findings may be helpful for counseling of men who choose to pursue active surveillance because they may be highly motivated to modify their behaviors," the authors write.
Several authors disclosed ties to the biopharmaceutical industry.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted October 2024
Read this next
Cerebroplacental Ratio Better Guides Delivery With Perceived Less Fetal Movement
THURSDAY, July 17, 2025 -- An additional ultrasound measurement to assess resistance in fetal blood vessels can improve the decision of whether to expedite birth when a woman in...
GLP-1 Receptor Agonist Use in T2D Tied to Increased Risk for GERD, GERD Complications
THURSDAY, July 17, 2025 -- For patients with type 2 diabetes, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are associated with an increased risk for gastroesophageal...
ENDO: Osteoporosis Treatment Benefits Elderly Patients With Fragility Fracture
THURSDAY, July 17, 2025 -- Patients with osteoporosis who suffer a fragility fracture at age 80 years or older have better five-year outcomes if they receive treatment for...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.