GLP-1 RA Use Linked to Retained Gastric Contents During Endoscopies
By Elana Gotkine HealthDay Reporter
FRIDAY, Oct. 4, 2024 -- Use of glucagon-like peptide 1 receptor agonists (GLP-1 RAs) is associated with the risk for retained gastric contents and inadequate bowel preparation during endoscopic procedures, according to a research letter published online Oct. 1 in JAMA Network Open.
Jason Nasser, M.D., from Cedars-Sinai Medical Center in Los Angeles, and colleagues examined the potential associations between GLP-1 RA use and risks for gastric food retention and periprocedural aspiration during esophagogastroduodenoscopies (EGDs), when EGD was combined with colonoscopy, and in colonoscopy alone in a retrospective, single-center cross-sectional study. Individuals taking GLP-1 RAs at the time of endoscopy were matched for age, body mass index subgroup, sex, and procedure with individuals in a control group (70 and 139 individuals, respectively).
Overall, 33 percent of the cohort underwent EGD, 33 percent underwent colonoscopy, and 34 percent underwent both. The researchers found that four of 23 individuals (17.4 percent) in the GLP-1 RA group undergoing EGD alone and none of 46 in the control group had food retention (odds ratio, 21.5). In combined EGD-colonoscopies, there was no food retention observed. Inadequate bowel preparation was more common in the GLP-1 RA group than the control group among individuals undergoing colonoscopy or combined EGD-colonoscopies (21.3 versus 6.5 percent; odds ratio, 3.9). There were no aspiration events, respiratory distress, or aspiration pneumonia visits.
"Contrary to previous reports, our study identified a clear association between GLP-1 RA use and unsatisfactory bowel preparation, which carries significant risks for missed lesions, patient dissatisfaction, and procedure cancellation, with wasted resources," the authors write.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted October 2024
Read this next
GLP-1 Receptor Agonist Use Linked to Lower Mortality in Seniors With Cancer, T2D
THURSDAY, July 24, 2025 -- For older patients with cancer and type 2 diabetes (T2D), glucagon-like peptide-1 receptor agonist (GLP-1 RA) use is associated with lower all-cause...
Random Forest AI Model Superior for Inpatient Mortality Prognostication in Cirrhosis
THURSDAY, July 24, 2025 -- For inpatients with cirrhosis, a machine learning (ML) model using random forest (RF) analysis is superior for prediction of inpatient mortality...
Inflammation and Nutrition-Based Scores Tied to Prognosis of Low-Risk Myelodysplastic Syndrome
THURSDAY, July 24, 2025 -- The Prognostic Nutritional Index (PNI) and systemic oxidative stress (SOS) score are independently associated with poorer prognosis of low-risk...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.