Skip to main content

Gastroesophageal Reflux Disease Increases Risk for Atrial Fibrillation

Medically reviewed by Carmen Pope, BPharm. Last updated on July 2, 2024.

By Lori Solomon HealthDay Reporter

TUESDAY, July 2, 2024 -- Gastroesophageal reflux disease (GERD) is associated with an increased incidence of atrial fibrillation, according to a study published online June 2 in Frontiers in Cardiovascular Medicine.

Lei Wang and Yi Wei Lu, from the Aerospace Center Hospital in Beijing, and colleagues assessed GERD’s role as a potential contributing factor in atrial fibrillation using a two-sample Mendelian randomization technique. The examination of the association of genetic variants with GERD used data from a genome-wide association study (GWAS) of 602,604 people, while data on the association between genetic variations and atrial fibrillation was obtained from a second GWAS involving 1.03 million participants.

The researchers found that Mendelian randomization analyses, using 76 single nucleotide polymorphisms as markers, revealed a relationship between genetically predicted GERD and a greater atrial fibrillation incidence (odds ratio, 1.165). There was no evidence of gene pleiotropy (intercept = 0.003). Similar results were seen in a sensitivity analysis.

"The Mendelian randomization analysis revealed a correlation between GERD and increased atrial fibrillation incidence, supporting the idea that treating patients with GERD as early as possible might reduce their chance of developing atrial fibrillation," the authors write.

Abstract/Full Text

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2025 HealthDay. All rights reserved.

Read this next

Faster Walking Pace Cuts Risk for Cardiac Arrhythmias

FRIDAY, April 25, 2025 -- Average and brisk walking pace are associated with a decreased risk for cardiac arrhythmias, according to a study published online April 15 in...

Most Patients Newly Diagnosed With A-Fib Do Not Receive Anticoagulants

WEDNESDAY, April 23, 2025 -- For patients newly diagnosed with atrial fibrillation (AF) during hospitalization for other causes, most are not dispensed anticoagulants in the year...

Lower Rates of Symptom Rebound Seen After H. Pylori Eradication in GERD

THURSDAY, March 6, 2025 -- For patients with gastroesophageal reflux disease (GERD), those with Helicobacter pylori infection have significantly lower rates of symptom rebound and...

More news resources

Subscribe to our newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.