Fish Oil Supplementation Cuts Measure of Prostate Cancer Progression
MONDAY, Dec. 23, 2024 -- A high omega-3, low omega-6 diet with fish oil supplementation for one year results in a significant reduction of a marker of prostate cancer progression among men enrolled in active surveillance (AS), according to a study published online Dec. 13 in the Journal of Clinical Oncology.
William J. Aronson, M.D., from the University of California, Los Angeles, and colleagues examined whether a high omega-3, low omega-6 fatty acid diet with fish oil capsules (D + FO) decreases proliferation (Ki-67) in prostate biopsies in men with prostate cancer over one year of AS. The analysis included 100 men with grade 1 or 2 prostate cancer who elected AS.
The researchers found that the Ki-67 index decreased in the D + FO group by approximately 15 percent from baseline to one year (1.34 to 1.14 percent at one year) and increased in the control group by approximately 24 percent from baseline to one year (1.23 to 1.52 percent at one year), yielding a statistically significant difference in the change of the Ki-67 index between the groups. For the secondary outcomes, grade group, tumor length, Decipher genomic score, and prostate-specific antigen did not significantly differ between the two groups. In the D + FO group, four patients withdrew from the trial because of adverse events related to the FO.
"These findings support future phase III trials incorporating this intervention in men on AS," the authors write.
Two authors disclosed ties to the pharmaceutical industry.
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