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Exposure to PFAS 'Forever Chemicals' in Pregnancy Could Boost Long-Term Obesity Risk

Medically reviewed by Carmen Pope, BPharm. Last updated on Sep 6, 2024.

By Dennis Thompson HealthDay Reporter

FRIDAY, Sept. 6, 2024 -- PFAS “forever chemicals” could cause pregnant women to experience long-term weight gain, increasing their risk of obesity in middle age, a new study warns.

Women with higher levels of PFAS in their blood during early pregnancy weighed more at the age of 50 than those with low levels, researchers reported Sept. 5 in the Journal of Clinical Endocrinology & Metabolism.

These women also carried more body fat at age 50, potentially making them more susceptible to obesity and heart problems later in life, researchers found.

“Our study supports the idea that pregnancy may be a sensitive period of PFAS exposure as it may be associated with long-term weight gain and subsequent adverse cardio-metabolic health outcomes in women,” said lead investigator Jordan Burdeau, a graduate research assistant with the Harvard T.H. Chan School of Public Health in Boston.

“Our findings may improve understanding of the effects of PFAS on cardio-metabolic health during pregnancy, which in turn may improve early prevention or detection of adverse cardio-metabolic health outcomes in women,” Burdeau added in a journal news release.

Per- and polyfluoroalkyl substances (PFAS) can be found in 99% of Americans, according to the Environmental Working Group.

There are thousands of different PFAS chemicals, the Environmental Protection Agency says. They can be found in drinking water as well as a wide range of consumer products including paper fast food wrappers, Teflon cookware, stain-resistant furniture and clothing, and cosmetics and personal care products.

They are called “forever chemicals” because PFAS doesn’t break down in the environment or in the human body. Instead, levels of the chemicals build up in the body over time.

These chemicals are known to disrupt hormones in humans. Studies have previously linked PFAS to decreased fertility in women, developmental effects in children, reduced immune response and increased risk of some cancers, the EPA says.

For this study, researchers studied nearly 550 pregnant women in their early 30s. They compared the women’s’ PFAS blood levels during pregnancy with their weight and heart health at age 50.

The study’s results jibe with earlier research linking PFAS to higher cholesterol levels and obesity, according to the EPA.

“It’s important to try to limit your PFAS exposure as it could reduce your risk of health issues later in life,” Burdeau said.

Sources

  • The Endocrine Society, news release, Sept. 5, 2024

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2025 HealthDay. All rights reserved.

Posted September 2024

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