EASD: Factors Linked to Lower-Limb Amputation ID'd in Diabetes
Medically reviewed by Drugs.com.
By Elana Gotkine HealthDay Reporter
WEDNESDAY, Aug. 23, 2023 -- For people with newly diagnosed diabetes, the risk for lower-limb amputation (LLA) is increased for those with older age, males, and divorced individuals, according to a study to be presented at the annual meeting of the European Association for the Study of Diabetes, being held Oct. 2 to 6 in Hamburg, Germany.
Stefan Jansson, Ph.D., from Örebro University in Sweden, and colleagues examined the association of demographic, socioeconomic, medical, and lifestyle risk factors with LLA in people with newly diagnosed diabetes using Swedish national register-linked data. The cohort consisted of 66,569 individuals aged 18 years or older with an incident diabetes diagnosis.
There were 133 LLAs during the median follow-up of four years. The researchers found that in a model mutually adjusting for all variables, positive associations were seen for higher age (hazard ratio [HR], 1.08 per year), being divorced versus married (HR, 1.67), and male sex (HR, 1.57). Compared with those with healthy feet, those with an increased foot risk at baseline had an increased risk for LLA (HR, 4.12, 8.26, and 11.24 for neuropathy/angiopathy, previous wounds, and ongoing severe foot disease, respectively). Compared with diet-only treatment, insulin treatment had an HR of 2.03. A significantly lower risk was seen for people with obesity versus those with normal weight (HR, 0.46). Compared with no smoking, smoking was associated with increased risk (HR, 1.99). Relative to daily physical activity, low physical activity (less than one time/week) was associated with increased risk (HR, 2.05).
"Lifestyle variables have a strong association with LLA, and an increase in physical activity, avoidance of being underweight, and smoking cessation may be impactful interventions to reduce the risk of LLA," the authors said in a statement.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted August 2023
Read this next
Patients Can Take GLP-1 RA Medications Before Surgery
WEDNESDAY, June 12, 2024 -- Glucagon-like peptide-1 receptor agonist (GLP-1 RA) medications do slow gastric emptying but not by enough to warrant discontinuing medications before...
Insulin-Treated T2D Patients Unwilling to Participate in Intensive Lifestyle Intervention
MONDAY, June 10, 2024 -- For adults with advanced, insulin-treated type 2 diabetes (T2D), willingness to participate in an intensive lifestyle intervention (ILI) is very low...
ENDO: Cardiovascular Events Occur Less Often With GLP1-RA, SGLT-2i for T2D, Liver Disease
FRIDAY, June 7, 2024 -- For adults with type 2 diabetes (T2D) and metabolic dysfunction-associated steatotic liver disease (MASLD), glucagon-like peptide 1 receptor agonists...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.