Early-Life Ozone Exposure Linked to Asthma, Wheeze at 4 to 6 Years Old
By Elana Gotkine HealthDay Reporter
THURSDAY, April 3, 2025 -- Early-life ozone (O3) exposure is associated with asthma and wheeze outcomes at 4 to 6 years of age, according to a study published online April 2 in JAMA Network Open.
Logan C. Dearborn, M.P.H., from the University of Washington in Seattle, and colleagues examined the associations between ambient O3 and subsequent asthma and wheeze outcomes -- independently and in mixture with fine particulate matter and nitrogen dioxide -- in a pooled multisite analysis across six U.S. cities.
The analytic sample included 1,188 participants. The mean O3 concentration was 26.1 parts per billion (ppb) in the first two years of life. The researchers found that 148 children had current asthma and 190 had current wheeze (12.3 and 15.8 percent, respectively) at age 4 to 6 years. Per 2 ppb higher O3 concentration, the odds ratios were 1.31 and 1.30 for current asthma and current wheeze, respectively, at age 4 to 6 years; for outcomes at 8 to 9 years and for sensitivity covariate adjustment, the associations were null. Higher exposure to O3 in mixture was associated with current asthma and wheeze in early childhood in Bayesian kernel machine regression.
"This analysis underscores the importance of better understanding the role of early-life exposure to ambient O3 in addressing risk factors for pediatric asthma in the U.S.," the authors write.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted April 2025
Read this next
GERD Linked to Increased Incidence of Pulmonary Disease
TUESDAY, Aug. 19, 2025 -- The presence of gastroesophageal reflux disease (GERD) is associated with an increased incidence of pulmonary diseases, but this effect may be attenuated...
Six in 10 Children With Asthma Meet Guideline Diagnostic Criteria
THURSDAY, Aug. 14, 2025 -- Roughly two-thirds of children with pediatrician-diagnosed asthma have a confirmed diagnosis in accordance with international guideline criteria...
Study IDs Inflammatory Pathways Contributing to Asthma Exacerbations in Children
TUESDAY, Aug. 12, 2025 -- Inflammatory pathways that contribute to asthma exacerbations have been identified in children with eosinophilic asthma receiving mepolizumab, according...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.