Skip to main content

Deprescribing Antihypertensives Not Tied to Hospitalization for Heart Attack, Stroke

By Lori Solomon HealthDay Reporter

Medically reviewed by Carmen Pope, BPharm. Last updated on Dec 3, 2024.

via HealthDay

TUESDAY, Dec. 3, 2024 -- Deprescribing antihypertensive medication is not associated with the risk for hospitalization for myocardial infarction (MI) or stroke in long-term care residents, according to a study published online Nov. 25 in JAMA Network Open.

Michelle C. Odden, Ph.D., from Stanford University in California, and colleagues compared the incidence of hospitalization for MI or stroke among long-term care residents who are deprescribed or continue antihypertensive therapy. The analysis included 13,096 U.S. veterans residing in long-term care (Oct. 1, 2006, to Sept. 30, 2019) taking at least one antihypertensive medication.

The researchers found that 17.8 percent of veterans were deprescribed antihypertensive medication during a period of 12 weeks. Over two years, a similar estimated unadjusted cumulative incidence of stroke or MI hospitalization was seen for residents who were and were not deprescribed antihypertensives (11.2 versus 8.8 percent). In fully adjusted models, the per-protocol analysis results showed no association of antihypertensive deprescribing with MI or stroke hospitalization (hazard ratio, 0.93; 95 percent confidence interval, 0.70 to 1.26).

"A randomized clinical trial would help address concerns about unmeasured confounding but could be challenging to implement in this complex population," the authors write. "More research is needed on deprescribing methods and potential consequences to inform this growing practice and inform patient and clinician shared decision-making."

Abstract/Full Text

Editorial

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2025 HealthDay. All rights reserved.

Read this next

Brain Age Gap May Mediate Influence of Cognitive Impairment Risk Factors

TUESDAY, June 24, 2025 -- The brain age gap (BAG) plays a role in mediating the influence of cognitive impairment risk factors on cognitive function, especially among individuals...

Hypertension Is Most Common Chronic Condition in People Aged 85 Years and Older

FRIDAY, June 20, 2025 -- Hypertension is the most common chronic condition among adults aged 85 years and older, with prevalence higher among women than men, according to a report...

Researchers Quantify Magnitude of Cardiovascular Risk Associated With Cannabis

WEDNESDAY, June 18, 2025 -- Cannabis use is associated with major adverse cardiovascular events (MACE), according to a systematic review based on real-world data published online...

More news resources

Subscribe to our newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.