Crisaborole Effective for Long-Term Maintenance in Mild-to-Moderate Eczema
Medically reviewed by Drugs.com.
By Elana Gotkine HealthDay Reporter
WEDNESDAY, June 28, 2023 -- Crisaborole is effective as a long-term maintenance therapy for pediatric and adult patients with mild-to-moderate atopic dermatitis (AD), according to a study published online May 15 in the American Journal of Clinical Dermatology.
Lawrence F. Eichenfield, M.D., from the University of California San Diego and Rady Children's Hospital-San Diego, and colleagues examined long-term efficacy and safety of crisaborole once daily (QD) versus vehicle QD as maintenance therapy for patients (aged ≥3 months) with mild-to-moderate AD. Eligible patients received crisaborole twice daily during an open-label run-in period of up to eight weeks and were then randomly assigned to receive crisaborole or vehicle QD (135 patients in each group).
The researchers found that patients who received crisaborole versus vehicle had longer median time of flare-free maintenance (111 versus 30 days). For patients who received crisaborole versus vehicle, the mean number of flare-free days was higher (234.0 versus 199.4 days). In addition, patients receiving crisaborole had a lower mean number of flares (0.95 versus 1.36). No clear trend was observed between the groups in maintenance of pruritus response. Crisaborole was well tolerated, with no new safety findings for use as maintenance treatment.
"Crisaborole QD is effective as a long-term maintenance therapy, demonstrating a significant reduction in the incidence of AD-related flares compared to vehicle in pediatric (aged ≥3 months) and adult patients with mild-to-moderate AD," the authors write.
Several authors disclosed ties to biopharmaceutical companies, including Pfizer, which manufactures crisaborole and funded the study.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted June 2023
Read this next
Coexistence of Psoriatic Arthritis, Atopic Dermatitis May Offer Treatment Insights
MONDAY, May 13, 2024 -- Psoriatic arthritis (PsA) and atopic dermatitis (AD) can coexist, and the presence of both conditions may mean special attention should be given to...
Systemic Antibiotics in First Year of Life Tied to Higher Atopic Dermatitis Risk
WEDNESDAY, May 8, 2024 -- Systemic antibiotic exposure in the first year of life is associated with higher atopic dermatitis (AD) risk in a dose-response fashion, according to a...
Stigma Affects Quality of Life in Children With Chronic Skin Conditions
TUESDAY, April 30, 2024 -- Health care professionals should consider stigmatization and bullying in assessing the social and mental health of children and adolescents with chronic...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.