Cannabidiol Safe, May Lower Anxiety in Advanced Breast Cancer
By Elana Gotkine HealthDay Reporter
FRIDAY, Dec. 20, 2024 -- For patients with advanced breast cancer and baseline clinical anxiety, cannabidiol (CBD) is safe and may reduce anxiety levels two to four hours after ingestion, according to a study published online Dec. 16 in JAMA Network Open.
Manan M. Nayak, Ph.D., from the Dana-Farber Cancer Institute in Boston, and colleagues randomly assigned 50 patients with advanced breast cancer and baseline clinical anxiety to receive oral CBD 400 mg (25 patients) or placebo (25 patients) within 48 hours before a scan assessing tumor burden.
The researchers found that the primary end point of change scores on the afraid subscale of the Visual Analog Mood Scale (VAMS) before and two to four hours after ingestion was numerically greater in the CBD arm, but did not differ significantly between the arms. Significantly lower VAMS afraid T-scores were seen for participants receiving CBD versus placebo when comparing anxiety levels two to four hours after study drug ingestion. There were no reports of grade 3 or 4 toxic effects.
"This preliminary randomized clinical trial establishes CBD as a treatment for anxiety for patients with breast cancer and has laid groundwork for a larger, more definitive trial to test the efficacy of oral CBD, 400 mg, in decreasing anxiety in this patient population," the authors write.
One author disclosed ties to the pharmaceutical industry.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted December 2024
Read this next
Worse Mental Health Trajectories Seen for Survivors of Teen, Young Adult Cancer
WEDNESDAY, May 28, 2025 -- Survivors of adolescent and young adulthood (AYA) cancer have significantly worse mental health trajectories into middle or older adulthood, according...
One-Week Radiotherapy for Breast Cancer Safe, Effective Up to 10 Years
TUESDAY, May 27, 2025 -- A five-fraction, one-week schedule of adjuvant breast radiotherapy is as safe and effective as a standard three-week schedule for patients with invasive...
Patients Who Fear Cataract Surgery Less Likely to Believe Surgery Will Improve Vision
TUESDAY, May 27, 2025 -- Neither health literacy nor understanding of cataract pathology is associated with fear of cataract surgery, according to a study published online March...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.